ginsenoside Rd
人参皂甙 Rd(ginsenoside Rd)
CAS: 52705-93-8
化学式: C48H82O18
| 中文名 | 人参皂甙 Rd |
| 英文名 | ginsenoside Rd |
| 别名 | 人参皂荚RD 绞股蓝总皂甙 人参皂苷Rd 人参皂甙 Rd 人参皂甙-RD标准品 人参皂苷RD(标准品) 人参皂苷RD(分析标准品) 人参皂苷RD(人参皂甙RD) GINSENOSIDE RD 人参皂苷RD |
| 英文别名 | ginsenoside Rd GINSENOSIDE RD GINSENOOSIDERD Gypenoside VIII Ginsenoside Rd 52705-93-8 xydammar-24-en-3-yl2-o-beta-d-glucopyranosyl- beta-d-glucopyranoside,(3-beta,12-beta)-20-(beta-d-glucopyranosyloxy)-12-hydro (3β,12β)-20-(β-D-Glucopyranosyloxy)-12-hydroxydammar-24-en-3-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranoside b-D-Glucopyranoside, (3b,12b)-20-(b-D-glucopyranosyloxy)-12-hydroxydammar-24-en-3-yl 2-O-b-D-glucopyranosyl- 2-o-beta-d-glucopyranosyl-(3beta,12beta)-20-(beta-d-glucopyranosyloxy)-12-hydroxydammara-24-en-3-yl-beta-d-glucopyranoside 2-O-beta-D-Glucopyranosyl-(3beta,12beta)-20-(beta-D-glucopyranosyloxy)-12-hydroxydammara-24-en-3-yl-beta-D-glucopyranoside beta-D-Glucopyranoside, (3-beta,12-beta)-20-(beta-D-glucopyranosyloxy)-12-hydroxydammar-24-en-3-yl 2-O-beta-D-glucopyranosyl- (8xi,9xi,12alpha,13alpha,14beta,17beta)-17-[(1S)-1-(beta-D-glucopyranosyloxy)-1,3,5-trimethylhex-4-en-1-yl]-12-hydroxy-4,4,10,14-tetramethylgonan-3-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranoside |
| CAS | 52705-93-8 |
| EINECS | 258-118-5 |
| 化学式 | C48H82O18 |
| 分子量 | 947.15 |
| InChI | InChI=1/C48H82O18/c1-21(2)15-22(3)17-48(8,66-43-40(60)37(57)34(54)28(19-50)62-43)24-11-13-47(7)23-9-10-30-45(4,5)31(12-14-46(30,6)25(23)16-26(52)32(24)47)64-44-41(38(58)35(55)29(20-51)63-44)65-42-39(59)36(56)33(53)27(18-49)61-42/h15,22-44,49-60H,9-14,16-20H2,1-8H3/t22?,23?,24-,25?,26-,27+,28+,29+,30?,31?,32+,33+,34+,35+,36-,37-,38-,39+,40+,41+,42-,43-,44-,46+,47+,48-/m0/s1 |
| 密度 | 1.38±0.1 g/cm3(Predicted) |
| 熔点 | 204～206℃ |
| 沸点 | 1015.6±65.0 °C(Predicted) |
| 比旋光度 | +19.38（c=1.03，methanol） |
| 闪点 | 570.9°C |
| 蒸汽压 | 0mmHg at 25°C |
| 溶解度 | DMSO (微溶) 、甲醇 (微溶) |
| 折射率 | 1.61 |
| 酸度系数 | 12.85±0.70(Predicted) |
| 存储条件 | Inert atmosphere,2-8°C |
| 稳定性 | 吸湿性 |
| 敏感性 | Easily absorbing moisture |
| 外观 | 固体 |
| 颜色 | White to Off-White |
| 物化性质 | 白色结晶粉末，易溶于甲醇、乙醇、水，不溶于乙醚、苯，来源于人参根茎，绞股蓝。 |
| MDL号 | MFCD00210508 |
| 危险品标志 | Xn - 有害物品 |
| 风险术语 | 22 - 吞食有害。 |
| 安全术语 | S2 - 避免儿童触及。 S45 - 若发生事故或感不适，立即就医(可能的话，出示其标签)。 |
| WGK Germany | 3 |
| 海关编号 | 29389090 |
| 参考资料 展开查看 | 1. 薛晓丽, 张心慧, 于加平, et al. 重金属胁迫对人参皂苷含量的影响. 2. 田静 任雨贺 刘淑莹 等. 人参皂苷Rc Rd Re对神经胶质瘤细胞增殖作用的影响[J]. 中成药 2020 042(003):751-754. 3. 何家乐,周思思,马增春,梁乾德,王宇光,谭洪玲,肖成荣,汤响林,高月.基于UPLC-Q-TOF/MS研究参附注射液的物质基础[J].中国药理学通报,2014,30(03):429-433. 4. 苗瑞, 吴冬雪, 王秋颖,等. 基于多壁碳纳米管的人参皂苷快速分离[J]. 高等学校化学学报, 2018. 5. 钟雅婷 茅仁刚 宋纯清 等. RP-HPLC同时测定西洋参总皂苷转化产物中人参皂苷Rg1 Rh1 Rd Rg3和C-K的含量[J]. 江西中医药 2012 43(8):61-64. 6. 李晓青 田雅娟 杜娟 等. 一测多评法测定人参花中7种人参皂苷含量[J]. 中草药 2019 v.50;No.659(24):213-217. 7. 徐灿辉, 何维为. 西洋参保健食品中7种人参皂苷的高效液相色谱法测定[J]. 食品与药品, 2015, 17(004):273-277. 8. 杨丽颖 郭伟英. HPLC-ELSD法同时测定益心宁神片中5种成分的含量[J]. 中药材 2015 38(012):2619-2622. 9. 韩铭鑫, 李方彤, 张琰,等. 稀有原人参二醇型皂苷的人肠道菌群生物转化[J]. 高等学校化学学报, 2019, 40(7). 10. 余健, 徐晓珍, 顾利强,等. 高效液相色谱-串联质谱法同时测定参麦注射液中9种皂苷[J]. 中华中医药学刊, 2014. 11. 方磊,陈红,余晓斌.高转化人参皂苷菌株筛选鉴定及发酵培养基优化[J].食品与发酵工业,2017,43(04):147-151. 12. 吴雨佳, 王令充, 张雯,等. 生物黏附性三七总皂苷-白及多糖-海藻酸钠复合微球的制备及表征[J]. 中草药, 2019, v.50;No.655(20):49-56. 13. 张艳欣, 朱国琴, 王丹丹. 均匀设计法优化林下山参中人参皂苷提取工艺的研究[J]. 上海医药, 2019, 040(015):89-92. 14. 赵昶灵, 杨生超, 陈中坚,等. 紫,绿三七的总花色苷和总皂苷含量及皂苷单体组成[J]. 中药材, 2014, 37(10):1749-1753. 15. 杨林, 徐晓珍, 陈劲柏,等. UHPLC法同时测定参麦注射液中8种人参皂苷[J]. 中成药, 2019. 16. 夏晚霞, 张尚微, 葛亚中,等. 乳酸菌发酵转化人参皂苷[J]. 现代食品科技, 2018, 34(09):136-142. 17. 邵紫君,李志满,于鹏程,陈建波,李珊珊,孙印石.氨基酸转化三七花中稀有人参皂苷及提取液对脂多糖诱导的RAW264.7细胞活性的影响[J].中草药,2021,52(03):702-710. 18. 张娜,黄鑫,郭云龙,越皓,刘淑莹.基于UPLC-QQQ-MS多指标统计分析研究不同生境人参中皂苷分布[J].特产研究,2020,42(06):48-54. 19. 乐世俊,王文晓,高欢,任继国,付瑞嘉,李佳佳,陈艳琰,唐于平.HPLC同时测定不同厂家丹七片中多个有效成分的含量[J].药物分析杂志,2020,40(12):2236-2243. 20. 屈青松,林峰,赵崇妍,马涛,宋帅,史新元.发酵乳杆菌发酵人参工艺优化及人参皂苷抗氧化活性测定[J].中成药,2020,42(10):2738-2743. 21. 杜静. 冠突散囊菌对中药材三七成分的转化及机理研究[D].贵州师范大学,2020. 22. 王艳,尉忠贤,李晶.HPLC法测定不同厂家振源片中人参皂苷的含量[J].西北药学杂志,2020,35(05):669-673. 23. Yao, Lu, et al. "Ginsenoside Rd ameliorates high fat diet‐induced obesity by enhancing adaptive thermogenesis in a cAMP‐dependent manner." Obesity 28.4 (2020): 783-792.https://doi.org/10.1002/oby.22761 24. Han, Xin, et al. "Biocatalytic production of compound K in a deep eutectic solvent based on choline chloride using a substrate fed-batch strategy." Bioresource technology 305 (2020): 123039.https://doi.org/10.1016/j.biortech.2020.123039 25. Bian, Minjuan, et al. "Combination of ginsenoside Rb1 and Rd protects the retina against bright light-induced degeneration." Scientific reports 7.1 (2017): 1-15.https://doi.org/10.1038/s41598-017-06471-x 26. Zhengming Qian, Qi Huang, Chunhong Li, Jing Chen, Gang Li, Hongyan Ma & Juying Xie (2020) Analysis of ginseng root and leaf by multiple columns and detections liquid chromatography, Journal of Liquid Chromatography & Related Technologies, 43:13-14, 464-473 27. Jin, Wenqi, et al. "Ginsenoside Rd attenuates ACTH-induced corticosterone secretion by blocking the MC2R-cAMP/PKA/CREB pathway in Y1 mouse adrenocortical cells." Life sciences 245 (2020): 117337.https://doi.org/10.1016/j.lfs.2020.117337 28. Yu, Jingping, et al. "Comprehensive Quality Evaluation of American Ginseng for Different Parts and Abnormal Trait Based on the Major Ginsenoside Contents and Morphological Characteristics." BioMed research international 2021 (2021).https://doi.org/10.1155/ 29. Yongshen Ren, Jiao Ai, Xinqiao Liu, Shuai Liang, Yao Zheng, Xin Deng, Yan Li, Jing Wang, Xukun Deng, Lin-Lin Chen,Anticoagulant active ingredients identification of total saponin extraction of different Panax medicinal plants based on grey relational anal 30. Wang, Xiaoping, et al. "Baoyuan decoction ameliorates apoptosis via AT1-CARP signaling pathway in H9C2 cells and heart failure post-acute myocardial infarction rats." Journal of ethnopharmacology 252 (2020): 112536.https://doi.org/10.1016/j.jep.2019.112536 31. Manying Wang, Jixiang Ren, Xuenan Chen, Jianzeng Liu, Xiaohao Xu, Xiangyan Li, Daqing Zhao, Liwei Sun, 20(S)-ginsenoside Rg3 promotes myoblast differentiation and protects against myotube atrophy via regulation of the Akt/mTOR/FoxO3 pathway, Biochemical Ph 32. Joo, Kyung-Mi, et al. "Pharmacokinetic study of ginsenoside Re with pure ginsenoside Re and ginseng berry extracts in mouse using ultra performance liquid chromatography/mass spectrometric method." Journal of pharmaceutical and biomedical analysis 51.1 (20 33. [IF=6.06] Jiahong Han et al."Compatibility effects of ginseng and Ligustrum lucidum Ait herb pair on hematopoietic recovery in mice with cyclophosphamide-induced myelosuppression and its material basis."J Ginseng Res. 2020 Mar;44:291 34. [IF=6.06] Jianbo Chen et al."Effects of processing method on the pharmacokinetics and tissue distribution of orally administered ginseng."J Ginseng Res. 2018 Jan;42:27 35. [IF=6.06] Yang Xiu et al."Simultaneous determination and difference evaluation of 14 ginsenosides in Panax ginseng roots cultivated in different areas and ages by high-performance liquid chromatography coupled with triple quadrupole mass spectrometer in the multipl 36. [IF=5.34] Shan-Shan Zhou et al."Stronger anti-obesity effect of white ginseng over red ginseng and the potential mechanisms involving chemically structural/compositional specificity to gut microbiota."Phytomedicine. 2020 Aug;74:152761 37. [IF=4.952] Jiali Chen et al."Ginsenosides and amino acids in flavored ginseng chips as affected by food formulation and processing technology."Lwt Food Sci Technol. 2015 Jun;62:517 38. [IF=4.36] Bin Ma et al."Sulfur fumigation reducing systemic exposure of ginsenosides and weakening immunomodulatory activity of ginseng."J Ethnopharmacol. 2017 Jan;195:222 39. [IF=3.998] Wang Peiwei et al."Ginsenoside Rd attenuates breast cancer metastasis implicating derepressing microRNA-18a-regulated Smad2 expression."Sci Rep-Uk. 2016 Sep;6(1):1-14 40. [IF=3.998] Bian Minjuan et al."Combination of ginsenoside Rb1 and Rd protects the retina against bright light-induced degeneration."Sci Rep-Uk. 2017 Jul;7(1):1-15 41. [IF=3.978] Hongfei Yu et al."The effect of triterpenoid saponins on pancreatic lipase in vitro: Activity, conformation, kinetics, thermodynamics and morphology."Biochem Eng J. 2017 Sep;125:1 42. [IF=3.935] Shan-Shan Zhou et al."Synchronous characterization of carbohydrates and ginsenosides yields deeper insights into the processing chemistry of ginseng."J Pharmaceut Biomed. 2017 Oct;145:59 43. [IF=1.967] Meijia Li et al."Brain Concentration of Ginsenosides and Pharmacokinetics after Oral Administration of Mountain-cultivated Ginseng."J Chin Chem Soc-Taip. 2017 Apr;64(4):395-403 44. [IF=9.642] Xin Han et al."Biocatalytic production of compound K in a deep eutectic solvent based on choline chloride using a substrate fed-batch strategy."Bioresource Technol. 2020 Jun;305:123039 45. [IF=6.558] Qingqing Song et al."Binary code, a flexible tool for diagnostic metabolite sequencing of medicinal plants."Anal Chim Acta. 2019 Dec;1088:89 46. [IF=6.06] Zhenzhuo Li et al."Ginsenosides repair UVB-induced skin barrier damage in BALB/c hairless mice and HaCaT keratinocytes."J Ginseng Res. 2021 May;: 47. [IF=5.878] Jianbo Chen et al."Protection by ginseng saponins against cyclophosphamide-induced liver injuries in rats by induction of cytochrome P450 expression and mediation of the l-arginine/nitric oxide pathway based on metabolomics."Phytother Res. 2021 Jun;35(6): 48. [IF=5.396] Hui Wang et al."Ginsenoside extract from ginseng extends lifespan and health span in Caenorhabditis elegans."Food Funct. 2021 Aug;12(15):6793-6808 49. [IF=5.34] You-Ping Wu et al."Evidences for the mechanism of Shenmai injection antagonizing doxorubicin-induced cardiotoxicity."Phytomedicine. 2021 Jul;88:153597 50. [IF=5.002] Lu Yao et al."Ginsenoside Rd Ameliorates High Fat Diet-Induced Obesity by Enhancing Adaptive Thermogenesis in a cAMP-Dependent Manner."Obesity. 2020 Apr;28(4):783-792 51. [IF=4.96] Manying Wang et al."20(S)-ginsenoside Rg3 promotes myoblast differentiation and protects against myotube atrophy via regulation of the Akt/mTOR/FoxO3 pathway."Biochem Pharmacol. 2020 Oct;180:114145 52. [IF=4.411] Jianbo Chen et al."Neuroprotective Effects of Red Ginseng Saponins in Scopolamine-Treated Rats and Activity Screening Based on Pharmacokinetics."Molecules. 2019 Jan;24(11):2136 53. [IF=4.36] Yongshen Ren et al."Anticoagulant active ingredients identification of total saponin extraction of different Panax medicinal plants based on grey relational analysis combined with UPLC-MS and molecular docking."J Ethnopharmacol. 2020 Oct;260:112955 54. [IF=4.142] Wang Chenxi et al."Rapid discovery of potential ADR compounds from injection of total saponins from Panax notoginseng using data-independent acquisition untargeted metabolomics."Analytical And Bioanalytical Chemistry. 2021 Oct 26 55. [IF=3.978] Weina Li et al."Ginsenoside CK production by commercial snailase immobilized onto carboxylated chitosan-coated magnetic nanoparticles."Biochem Eng J. 2021 Oct;174:108119 56. [IF=3.935] Ruimei Lin et al."Global identification and determination of the major constituents in Kai-Xin-San by ultra-performance liquid chromatography-quadrupole-Orbitrap mass spectrometry and gas chromatography-mass spectrometry."J Pharmaceut Biomed. 2021 Nov;206 57. [IF=3.659] Zhang Sheng et al."Protective effect of Shenmai injection on doxorubicin-induced cardiotoxicity via regulation of inflammatory mediators."Bmc Complem Altern M. 2019 Dec;19(1):1-10 58. [IF=3.647] Wenqi Jin et al."Ginsenoside Rd attenuates ACTH-induced corticosterone secretion by blocking the MC2R-cAMP/PKA/CREB pathway in Y1 mouse adrenocortical cells."Life Sci. 2020 Mar;245:117337 59. [IF=3.645] Mengmeng Jia et al."UHPLC coupled with mass spectrometry and chemometric analysis of Kang-Ai injection based on the chemical characterization, simultaneous quantification, and relative quantification of 47 herbal alkaloids and saponins."J Sep Sci. 2020 Ju 60. [IF=3.503] Jiajia Dong et al."Comparative pharmacokinetic analysis of raw and steamed Panax notoginseng roots in rats by UPLC-MS/MS for simultaneously quantifying seven saponins."Pharm Biol. 2021;59(1):653-661 61. [IF=3.361] Yuhao Zhang et al."An integrated approach for structural characterization of Gui Ling Ji by traveling wave ion mobility mass spectrometry and molecular network."Rsc Adv. 2021 Apr;11(26):15546-15556 62. [IF=3.21] Ma Zhu et al."Transformation of ginsenoside via deep eutectic solvents based on choline chloride as an enzymatic reaction medium."Bioproc Biosyst Eng. 2020 Jul;43(7):1195-1208 63. [IF=2.629] Zhang Meiyu et al."In Vitro Transformation of Protopanaxadiol Saponins in Human Intestinal Flora and Its Effect on Intestinal Flora."Evid-Based Compl Alt. 2021;2021:1735803 64. [IF=2.408] Fang-Tong Li et al."In Vitro Effects of Ginseng and the Seed of Zizyphus jujuba var. spinosa on Gut Microbiota of Rats with Spleen Deficiency."Chem Biodivers. 2020 Sep;17(9):e2000199 65. [IF=1.934] Zhang Chen et al."Biotransformation of ginsenoside Rc to Rd by endophytic bacterium Bacillus sp. G9y isolated from Panax quinquefolius."Anton Leeuw Int J G. 2021 Apr;114(4):437-444 66. [IF=1.312] Zhengming Qian et al."Analysis of ginseng root and leaf by multiple columns and detections liquid chromatography."Journal Of Liquid Chromatography & Related Technologies. 2020 Mar 02 67. [IF=4.432] Shuai Zhang et al."Ginsenoside Rf inhibits human tau proteotoxicity and causes specific LncRNA, miRNA and mRNA expression changes in Caenorhabditis elegans model of tauopathy."Eur J Pharmacol. 2022 May;922:174887 68. [IF=2.419] Yinping Jin et al."Dynamic changes of ginsenosides in Panax quinquefolius fruit at different development stages measured by UHPLC-Orbitrap MS."Rapid Communications In Mass Spectrometry. 2022 Feb 17 69. [IF=6.06] Qingxia Huang et al."Major ginsenosides from Panax ginseng promote aerobic cellular respiration and SIRT1-mediated mitochondrial biosynthesis in cardiomyocytes and neurons."J Ginseng Res. 2022 Feb;: 70. [IF=7.514] Di Qu et al."Sediment formation and analysis of the main chemical components of aqueous extracts from different parts of ginseng roots."Food Chem. 2022 Jan;:132146 71. [IF=6.06] Zhu Zhu et al."Target engagement of ginsenosides in mild cognitive impairment using mass spectrometry-based drug affinity responsive target stability."J Ginseng Res. 2021 Dec;: 72. [IF=5.293] Zhou Shuhui et al."Application of Ginsenoside Rd in Periodontitis With Inhibitory Effects on Pathogenicity, Inflammation, and Bone Resorption."Frontiers in Cellular and Infection Microbiology. 2022 Apr;0:387 73. [IF=5.811] He Zhang et al."Prevention Effect of Protopanaxadiol-Type Saponins Saponins and Protopanaxatriol-Type Saponins on Myelosuppression Mice Induced by Cyclophosphamide.."Frontiers in Pharmacology. 2022 Apr;13:845034-845034 74. [IF=4.35] Di Qu et al."Analysis of Key Chemical Components in Aqueous Extract Sediments of Panax Ginseng at Different Ages."Foods. 2022 Jan;11(8):1161 75. [IF=6.576] Zhi-man Li et al."Transformation Mechanism of Rare Ginsenosides in American Ginseng by Different Processing Methods and Antitumour Effects."Frontiers in Nutrition. 2022; 9: 833859 76. 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ginsenoside Rd - 简介
人参皂甙（Rd）是在人参中发现的一种活性成分，属于皂甙类化合物。它是人参中主要的皂甙之一，具有许多药理活性。
人参皂甙Rd具有多种药理作用，包括抗炎、抗氧化、抗肿瘤、抗疲劳和增强免疫系统功能等。它还有助于改善心脑血管循环、降低血压、促进血液循环以及保护肝脏和胃黏膜等作用。
制取人参皂甙Rd的方法主要有萃取和分离纯化。一般来说，通过选择性提取和纯化操作，可以从人参中分离出Rd并获得高纯度的化合物。
人参皂甙Rd的安全性，研究表明其具有较好的安全性和耐受性，一般情况下不会引起严重的副作用。
人参皂甙Rd具有多种药理作用，包括抗炎、抗氧化、抗肿瘤、抗疲劳和增强免疫系统功能等。它还有助于改善心脑血管循环、降低血压、促进血液循环以及保护肝脏和胃黏膜等作用。
制取人参皂甙Rd的方法主要有萃取和分离纯化。一般来说，通过选择性提取和纯化操作，可以从人参中分离出Rd并获得高纯度的化合物。
人参皂甙Rd的安全性，研究表明其具有较好的安全性和耐受性，一般情况下不会引起严重的副作用。
最后更新：2024-04-09 21:54:55
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产品名: Ginsenoside Rd 去供应商网站查看 询盘CAS: 52705-93-8
产地: 美国
包装: 10 mM * 1 mL;1 mg;5 mg;10 mg;25 mg;50 mg;100 mg
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产品名: 人参皂苷Rd(10mM in DMSO,无菌) 去供应商网站查看 询盘CAS: IG02201
产地: 北京
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提供多种规格现货供应
产品名: Ginsenoside Rd 去供应商网站查看 询盘CAS: 52705-93-8
产地: 美国
包装: 10 mM * 1 mL;1 mg;5 mg;10 mg;25 mg;50 mg;100 mg
规格: HY-N0043
库存: 现货，货期：1-2天
电话: 021-38924433; 021-58955995
手机: 18019480960
电子邮件: sales@medchemexpress.cn
产品描述: 产品覆盖：8万多种抑制剂，11000+靶点蛋白，数百款试剂盒，200+生物活性化合物库，天然产物，抗体等. 纯度: 99.88%
提供多种规格现货供应
产品名: 人参皂苷Rd(10mM in DMSO,无菌) 去供应商网站查看 询盘CAS: IG02201
产地: 北京
包装: 1ml/瓶
规格: IG02201-1ml
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