GLUMETINIB (SCC244)_化工百科

中文名	Glumetinib
英文名	Glumetinib
别名	谷美替尼化合物GLUMETINIB 6-(1-甲基-1H-吡唑-4-基)-1-((6-(1-甲基-1H-吡唑-4-基)咪唑并[1,2-A]吡啶-3-基)磺酰基)-1H-吡唑[4,3-B]吡啶
英文别名	SCC244 Glumetinib Gumarontinib GLUMETINIB (SCC244) 6-(1-Methyl-1H-pyrazol-4-yl)-1-((6-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-a]pyridin-3-yl)sulfonyl)-1H-pyrazolo[4,3-b]pyridine 1H-Pyrazolo[4,3-b]pyridine, 6-(1-methyl-1H-pyrazol-4-yl)-1-[[6-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-a]pyridin-3-yl]sulfonyl]-
CAS	1642581-63-2
化学式	C21H17N9O2S
分子量	459.48
密度	1.61±0.1 g/cm3(Predicted)
溶解度	溶于DMSO (>25 mg/ml)
酸度系数	0.09±0.10(Predicted)
存储条件	-20°C
稳定性	稳定1年的供应。DMSO中的溶液可以在-20 °C下储存长达1个月。
外观	固体
颜色	Beige
靶点	IC50: 0.42 nM (c-Met kinase)
体外研究	在具有扩增MET基因的EBC-1、MKN-45细胞和HGF刺激的U87MG细胞中，SCC244强烈抑制c-Met、AKT和ERK磷酸化。SCC244可对c-Met驱动的癌细胞增殖有选择性和深刻影响。SCC244抑制依赖于c-Met的诸如转移和血管生成等肿瘤表型。
体内研究	在人源肿瘤细胞或非小细胞肺癌的移植瘤模型中、或是由MET异常所驱动的肝癌患者肿瘤组织中，SCC244在各种耐受剂量下都具有强效的抗肿瘤活性。SCC244可通过抗增殖和抗血管新生抑制c-MET下游通路。
参考资料展开查看	[1]. Ai J, et al. Preclinical Evaluation of SCC244 (Glumetinib), a Novel, Potent, and Highly Selective Inhibitor of c-Met in MET-dependent Cancer Models. Mol Cancer Ther. 2018 Apr;17(4):751-762.

GLUMETINIB (SCC244) - 配置溶液浓度参考

	1mg	5mg	10mg
1 mM	2.176 ml	10.882 ml	21.764 ml
5 mM	0.435 ml	2.176 ml	4.353 ml
10 mM	0.218 ml	1.088 ml	2.176 ml
5 mM	0.044 ml	0.218 ml	0.435 ml

最后更新：2024-01-02 23:10:35

GLUMETINIB (SCC244) - 细胞实验

Cells were seeded in 96-well plates at a low density in growth media. The next day, appropriate controls or designated concentrations of compounds were added to each well, and the cells were incubated for 72 hours. HUVECs (passage 3) were seeded in 96-well plates in growth media overnight and transferred to serum-free media for 24 hours. The following day, appropriate controls or designated concentrations of compounds were added to each well, and HGF was added to designated wells at 100 ng/mL. The cells were incubated for 48 hours. Finally, cell proliferation was determined using a sulforhodamine B assay, a thiazolyl blue tetrazolium bromide assay or a cell counting kit (CCK-8) assay.

最后更新：2023-08-16 21:32:38

GLUMETINIB (SCC244) - 动物实验

To assess the pharmacodynamics of SCC244 in tumors, mice bearing established xenograft tumors were treated with a single dose of the compound at 10 or 2.5 mg/kg, and tumors were harvested at several time points. At a designated time following administration, mice were humanely euthanized, and their tumors were resected. The tumors were snap-frozen in liquid nitrogen and then homogenized in 500 μL of protein extraction solution (radioimmunoprecipitation assay, RIPA). The tumor extracts were then subjected to Western blot analysis. The individual bands of phospho-c-Met, phospho-AKT, and phospho-ERK were scanned and quantified using Gel Pro Analyzer software. The relative tyrosine phosphorylation of each sample at the indicated time points was then calculated, with the average value of vehicle-treated sample used as 100%.

最后更新：2023-08-16 21:32:38

北京索莱宝科技有限公司

现货供应

产品名: Glumetinib 去供应商网站查看询盘
CAS: 1642581-63-2
产地: 北京
包装: 盒
规格: IG1620-1mg,1mg
价格: 电话、微信、QQ、邮件
库存: 现询
电话: 010-50973130
手机: 17801761073(微信同号)
电子邮件: 3193328036@qq.com
QQ: 3193328036

微信: 17801761073
产品描述: 产品覆盖：小分子化合物、分析对照品、染色试剂、生化试剂盒、细胞生物学、分子生物学、抗体、蛋白、多肽、ELISA试剂盒、微生物培养、化学合成、仪器耗材、CRO技术更多

MedChemExpress

现货供应

产品名: Glumetinib 去供应商网站查看询盘
CAS: 1642581-63-2
产地: 美国
包装: 10 mM * 1 mL;1 mg;5 mg;10 mg;25 mg;50 mg
规格: HY-116000
价格: 询价
库存: 现货，货期：1-2天
电话: 021-38924433; 021-58955995
手机: 18019480960
电子邮件: sales@medchemexpress.cn
产品描述: 产品覆盖：8万多种抑制剂，11000+靶点蛋白，数百款试剂盒，200+生物活性化合物库，天然产物，抗体等. 纯度: 99.92%

上海吉至生化科技有限公司

现货供应

产品名: 谷美替尼去供应商网站查看询盘
CAS: 1642581-63-2
产地: 中国上海
包装: 50mg
价格: 面议、电联、微信、QQ
库存: 3个工作日
电话: 400-900-4166
手机: 18017137653
电子邮件: 3007523013@qq.com
QQ: 3007523013

微信: 18017137653
产品描述: 中文名称：化合物NLG802英文名称：NLG802CAS:1642581-63-2产地：中国上海货期：3个工作日规格：100mg联系方式：面议、电联、微信、QQ 更多

上海麦克林生化科技股份有限公司

现货供应

产品名: Glumetinib 去供应商网站查看询盘
CAS: 1642581-63-2
产地: 上海
规格: G795743
价格: 1ml-786,10mg-425,50mg-1079
库存: 7天内发货
电话: 13816333479/17821173903
手机: 13816333479/17821173903
电子邮件: wangrui@macklin.cn
QQ: 2881510266

微信: 19863730987/17821173903

上海源叶生物科技有限公司

现货供应

产品名: Glumetinib 去供应商网站查看询盘
CAS: 1642581-63-2
产地: 上海
规格: 98%
价格: 5mg 480,10mg 800,25mg 1600,100mg 4800
库存: 现货
电话: 18301782025
手机: 18301782025
电子邮件: 3008007403@qq.com
QQ: 3008007403