AVIPTADIL ACETATE 阿肽地尔
阿肽地尔(AVIPTADIL)
CAS: 40077-57-4
化学式: C147H238N44O42S
性质
- 本品是二十八肽，属于胰泌素族。结构与肠促胰液肽和胰高血糖素类似。它在体内分布极其广泛，大多数系统、器官内均有VIP神经分布，甚至在中性白细胞和肥大细胞内也含有。整个胃肠道从口腔的唾液腺到直肠均有VIP免疫反应活性物。以十二指肠含量最高，其次回肠。它在循环血液中的基础浓度很低，半衰期为(0. 85土0.12) min，肝、肾、脑均清除它。
- VIP对消化系统的作用是抑制食管下括约肌、胃、小肠环状肌、胆囊和大肠肛门括约肌的收缩；促进肠黏膜分泌水和电解质；刺激胰腺外分腺、胆汁和小肠水和电解质分泌；抑制胃分泌胃酸、水和电解质；刺激胃肠内分泌细胞分泌胰岛素、胰高血糖素、生长抑素和胰多肽，兴奋肠神经元。对循环和呼吸系统，VIP对心肌有中度正性肌力作用，增加心输出量；对大多数血管床有舒张作用，能降低舒张压和平均动脉压，舒张气管和支气管平滑肌，增加通气量；对神经内分泌的影响是刺激垂体释放催乳素、生长激素、ACTH和LH，刺激肾旁球细胞释放肾素。
用途
测定血浆VIP浓度可作为VIP瘤的诊断措施，也可作为治疗或肿瘤增生情况的指标。
| 中文名 | 阿肽地尔 |
| 英文名 | AVIPTADIL |
| 别名 | 阿肽地尔 血管活性肠肽 醋酸阿肽地尔 血管活性肠肽(抗体) 醋酸阿肽地尔 40077-57-4 AVIPTADIL ACETATE 阿肽地尔 血管活性肠肽(VIP)检测试剂盒( ELISA 方法) |
| 英文别名 | AVIPTADIL Aviptadil Acetate VASOACTIVE INTESTINAL PEPTIDE VASOACTIVE INTESTINAL PEPTIDE, PORCINE VASOACTIVE INTESTINAL PEPTIDE (HUMAN, PORCINE) VASOACTIVE INTESTINAL PEPTIDE HUMAN, PORCINE, RAT VASOACTIVE INTESTINAL PEPTIDE, HUMAN, PORCINE, AND RAT VASOACTIVE INTESTINAL PEPTIDE, HUMAN, PORCINE, RAT, OVINE VASOACTIVE INTESTINAL PEPTIDE (HUMAN, BOVINE, PORCINE, RAT) VASOACTIVE INTESTINAL PEPTIDE (HUMAN, PORCINE) (BOVINE, RAT, CANINE) |
| CAS | 40077-57-4 |
| 化学式 | C147H238N44O42S |
| 分子量 | 3325.8 |
| InChI | InChI=1/C147H237N43O43S/c1-18-75(12)115(142(229)180-96(56-72(6)7)131(218)183-104(145(232)233)63-110(155)200)188-139(226)106(68-192)185-134(221)101(62-109(154)199)177-130(217)95(55-71(4)5)174-132(219)97(58-81-37-41-84(195)42-38-81)175-125(212)88(33-23-26-49-149)167-123(210)89(34-24-27-50-150)171-140(227)113(73(8)9)186-118(205)76(13)164-121(208)93(47-53-234-17)170-127(214)92(45-46-107(152)197)169-122(209)87(32-22-25-48-148)166-124(211)90(35-28-51-161-146(156)157)168-129(216)94(54-70(2)3)173-126(213)91(36-29-52-162-147(158)159)172-143(230)116(78(15)193)189-136(223)98(59-82-39-43-85(196)44-40-82)176-133(220)100(61-108(153)198)178-135(222)103(65-112(203)204)182-144(231)117(79(16)194)190-137(224)99(57-80-30-20-19-21-31-80)181-141(228)114(74(10)11)187-119(206)77(14)165-128(215)102(64-111(201)202)179-138(225)105(67-191)184-120(207)86(151)60-83-66-160-69-163-83/h19-21,30-31,37-44,66,69-79,86-106,113-117,191-196H,18,22-29,32-36,45-65,67-68,148-151H2,1-17H3,(H2,152,197)(H2,153,198)(H2,154,199)(H2,155,200)(H,160,163)(H,164,208)(H,165,215)(H,166,211)(H,167,210)(H,168,216)(H,169,209)(H,170,214)(H,171,227)(H,172,230)(H,173,213)(H,174,219)(H,175,212)(H,176,220)(H,177,217)(H,178,222)(H,179,225)(H,180,229)(H,181,228)(H,182,231)(H,183,218)(H,184,207)(H,185,221)(H,186,205)(H,187,206)(H,188,226)(H,189,223)(H,190,224)(H,201,202)(H,203,204)(H,232,233)(H4,156,157,161)(H4,158,159,162)/t75-,76-,77-,78+,79+,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,113-,114-,115-,116-,117-/m0/s1 |
| InChIKey | HEOYHMUESMJFDC-RIWXPGAOSA-N |
| 密度 | 1.47±0.1 g/cm3(Predicted) |
| 溶解度 | 1% 乙酸: 可溶0.1%，澄清，无色 |
| 存储条件 | −20°C |
| 外观 | 粉末 |
| MDL号 | MFCD00167535 |
| 体外研究 | Aviptadil inhibits the basal proliferation of pulmonary arterial smooth muscle cells (PASMC) and the mobilization of intracellular free calcium concentration in these cells in a dose-dependent manner.Aviptadil (1 nM-10 μM) produces a concentration-dependent inhibition of CSE-induced cell death in L2 cells. At 10 μM, Aviptadil reduces CSE-stimulated MMP activity and caspase-3 activation in L2 cells.Aviptadil (10 nM-100 μM) attenuates lipopolisaccharide (LPS)-induced MMP-9 activity and its expression by alveolar macrophages (AM) in rats. |
| 体内研究 | Aviptadil (1, 3 and 10 mg/kg; intravenous bolus injection) is injected into a tail vein. No-effect dose level is 1 mg/kg. Dose level with first intolerance reactions 3 mg/kg, Lowest lethal dose level is >10 mg/kg. i.v. LD 50 of Aviptadil is >10 mg/kg in males, females and male and female combined after 24 hours and 14 days.Aviptadil (intravenous bolus injection) at 3 mg causes slightly reduced motility, slight ataxia and slight dyspnoea in all 5 male and 5 female animals 15 to 30 minutes after administration. At 10 mg, Aviptadil reveals slightly reduced motility, slight ataxia, and slight dyspnoea 15 to 60 minutes and slightly reduces muscle tone 15 to 30 minutes after administration, respectively, in all male and female animals.Nose-only inhalation exposure of CD1 mice to aerosolized.Aviptadil at a dose of 1546 µg/kg/day is well tolerated and produces no apparent changes in any of the parameters evaluated. No changes are observed after a single dose administration as high as 3920 µg/kg/day. The no-observable-adverse-effect level (NOAEL) is considered to be at least 3920 µg/kg/day fore an acute exposure and 1546 µg/kg/day for a 10 day repeated exposure. |
| WGK Germany | 3 |
| 参考资料 展开查看 | 1. 汪婷婷,张卫平,申国明,武松,程玲,黄金玲,陆婷婷,陈琛,吕丹丽.黄芪建中汤对脾气虚证大鼠Leptin-NPY/VIP/GAS信号传导通路及胸腺指数、脾指数的影响[J].辽宁中医药大学学报,2015,17(12):31-35. |
AVIPTADIL ACETATE 阿肽地尔 - 性质
可信数据
- 本品是二十八肽，属于胰泌素族。结构与肠促胰液肽和胰高血糖素类似。它在体内分布极其广泛，大多数系统、器官内均有VIP神经分布，甚至在中性白细胞和肥大细胞内也含有。整个胃肠道从口腔的唾液腺到直肠均有VIP免疫反应活性物。以十二指肠含量最高，其次回肠。它在循环血液中的基础浓度很低，半衰期为(0. 85土0.12) min，肝、肾、脑均清除它。
- VIP对消化系统的作用是抑制食管下括约肌、胃、小肠环状肌、胆囊和大肠肛门括约肌的收缩；促进肠黏膜分泌水和电解质；刺激胰腺外分腺、胆汁和小肠水和电解质分泌；抑制胃分泌胃酸、水和电解质；刺激胃肠内分泌细胞分泌胰岛素、胰高血糖素、生长抑素和胰多肽，兴奋肠神经元。对循环和呼吸系统，VIP对心肌有中度正性肌力作用，增加心输出量；对大多数血管床有舒张作用，能降低舒张压和平均动脉压，舒张气管和支气管平滑肌，增加通气量；对神经内分泌的影响是刺激垂体释放催乳素、生长激素、ACTH和LH，刺激肾旁球细胞释放肾素。
最后更新：2024-01-02 23:10:35
AVIPTADIL ACETATE 阿肽地尔 - 配置溶液浓度参考
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 0.301 ml | 1.503 ml | 3.007 ml |
| 5 mM | 0.06 ml | 0.301 ml | 0.601 ml |
| 10 mM | 0.03 ml | 0.15 ml | 0.301 ml |
| 5 mM | 0.006 ml | 0.03 ml | 0.06 ml |
最后更新：2024-01-02 23:10:35
AVIPTADIL ACETATE 阿肽地尔 - 用途
可信数据
测定血浆VIP浓度可作为VIP瘤的诊断措施，也可作为治疗或肿瘤增生情况的指标。
最后更新：2022-01-01 11:11:48
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