液体制剂为淡红或淡黄色澄明液体;冻干制剂为淡黄或淡红色疏松团块,加稀释液后迅速溶解。
本品系用绵羊红细胞作为抗原接种兔,采血,分离得血清,经冷冻真空干燥制成,或加入甘油制成液体制剂。冻干制剂使用时加入等量生理盐水。
液体溶血素2~8℃保存,有效期为12个月。冻干溶血素8℃以下保存,有效期为60个月。
中文名 | 链球菌溶血素 |
英文名 | streptolysin O gamma-irradiated |
别名 | 链球菌 溶血素 O 链球菌溶素O 链球菌溶血素 链球菌溶血素O 化合物 T19565 ATCC 15300 链球菌 |
英文别名 | STREPTOLYSIN O Einecs 308-500-3 Streptococcus sp. STREPTOLYSIN O REAGENT STREPTOLYSIN O GAMMA-IRRADIATED streptolysin O gamma-irradiated Hemolysins O, Streptococcus group A streptolysin O from streptococcus*pyogenes STREPTOLYSIN O FROM STREPTOCOCCUS*PYOGEN ES Native Streptococcus pyogenes Streptolysin O |
CAS | 98072-47-0 |
EINECS | 308-500-3 |
溶解度 | H2O: 可溶物1mg/mL |
存储条件 | 2-8°C |
外观 | 冻干粉 |
颜色 | white |
体外研究 | Streptolysin O is a labile toxin, and, with time, activity is irreversibly lost. The rate of activity loss is slowed by incubation with 0.1 M 2-mercaptoethanol or 0.01 M ethylenediaminetetraacetic acid (EDTA). Streptolysin O, belongs to the group of thiol-activated toxins, is a secreted virulence factor of GAS that induces apoptosis in neutrophils and macrophages at later time points (~4 h). Streptolysin O induces eukaryotic cell lysis in a cholesterol-dependent manner, is highly upregulated in the GAS M1T1 clone during bloodstream dissemination. Streptolysin O is known to promote Group A Streptococcus (GAS) resistance to phagocytic clearance by neutrophils, a critical first element of host defense against invasive bacterial infection. |
危险品运输编号 | UN 2811PIH 6.1 / PGI |
WGK Germany | 3 |
液体制剂为淡红或淡黄色澄明液体;冻干制剂为淡黄或淡红色疏松团块,加稀释液后迅速溶解。
本品系用绵羊红细胞作为抗原接种兔,采血,分离得血清,经冷冻真空干燥制成,或加入甘油制成液体制剂。冻干制剂使用时加入等量生理盐水。
液体溶血素2~8℃保存,有效期为12个月。冻干溶血素8℃以下保存,有效期为60个月。