中文名 | 异甘草素 |
英文名 | Isoliquiritigenin |
别名 | 异甘草素 4'-三羟基查尔酮 4,2',4'-三羟基查耳酮 ISOLIQUIRITIGENIN 异甘草素 异甘草苷元,4,2',4'-三羟基查耳酮,4,2',4'-三羟基查耳酮 (E)-1-(2,4-二羟基苯基)-3-(4-羟基苯基)-2-丙烯-1-酮 异甘草素(异甘草苷元,4,2',4'-三羟基查耳酮,4,2',4'-三羟基查耳酮) |
英文别名 | gu17 Isoliquiritigenin Isqliquiritigenin ISOLIQUIRITIGENIN(P) ISOLIQUIRITIGENIN(RG) (E)-2',4,4'-Trihydroxychalcone ISOLIQUIRTEGENIN (2',4,4'-TRIHYDROXYCHAL (E)-1-(2,4-Dihydroxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one, 4,2μ,4μ-Trihydroxychalcone |
CAS | 961-29-5 |
EINECS | 607-884-2 |
化学式 | C15H12O4 |
分子量 | 256.25 |
InChI | InChI=1/C15H12O4/c16-11-4-1-10(2-5-11)3-8-14(18)13-7-6-12(17)9-15(13)19/h1-9,16-17,19H/b8-3+ |
InChIKey | DXDRHHKMWQZJHT-FPYGCLRLSA-N |
密度 | 1.384±0.06 g/cm3(Predicted) |
熔点 | 206-210°C |
沸点 | 504.0±42.0 °C(Predicted) |
溶解度 | H2O: <0.1 mg/mL |
酸度系数 | 7.50±0.35(Predicted) |
存储条件 | 2-8°C |
敏感性 | Light Sensitive & Hygroscopic |
外观 | 粉末 |
颜色 | yellow to orange |
BRN | 1914296 |
物化性质 | 黄色结晶粉末,可溶于甲醇、乙醇、DMSO等有机溶剂,来源于甘草,石竹。 |
MDL号 | MFCD00075907 |
体外研究 | Isoliquiritigenin通过抑制大鼠晶状体醛糖还原酶可能能够有效预防糖尿病并发症,IC50为320 nM,并且能够预防山梨糖醇在人类红细胞中的积累,IC50为2.0 μM。 Isoliquiritigenin通过抑制单酚酪氨酸酶和二酚酪氨酸酶的活性可以用作美白剂,IC50为8.1 μM。 在DU145和LNCaP 细胞系中,Isoliquiritigenin诱导细胞周期停滞并抑制细胞生长。在人类胃癌MGC-803细胞中, Isoliquiritigenin通过增加细胞内游离钙离子浓度,并降低线粒体膜电位(Deltapsi(m))而诱导细胞凋亡。 |
体内研究 | LD50: 小鼠>6克/千克(灌胃) |
风险术语 | 36/37/38 - 刺激眼睛、呼吸系统和皮肤。 |
安全术语 | S26 - 不慎与眼睛接触后,请立即用大量清水冲洗并征求医生意见。 S37 - 戴适当手套。 |
WGK Germany | 3 |
RTECS | FL7080000 |
海关编号 | 29145090 |
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