中文名 | 盐酸依氟鸟氨酸一水合物 |
英文名 | Eflornithine HCl |
别名 | 盐酸依氟鸟胺酸 依氟鸟氨酸盐酸盐一水物 盐酸依氟鸟氨酸一水合物 依氟鸟氨酸盐酸盐一水合物 依氟鸟氨酸盐酸盐一水合酸物 2-二氟甲基-DL-鸟氨酸盐酸盐一水合物 2,5-二氨基-2-(二氟甲基)五烯酸盐酸盐水合物 |
英文别名 | DMFO HCl Eflornithine HCl DFMO EFLORNITHINE DFMO Eflornithine Eflornithine hydrochloride hydrate H-alpha-Difluoro-Me-DL-Orn-OH.HCl.H2O Eflornithine hydrochloride monohydrate H-alpha-Difluoro-Me-DL-Orn-OH . HCl . H2O 2,5-diamino-2-(difluoromethyl)pentanoic acid eflornithine,Eflornithinehydrochloridehydrate 2-(Difluoromethyl)ornithine hydrochloride hydrate |
CAS | 96020-91-6 62878-23-9 |
化学式 | C6H15ClF2N2O3 |
分子量 | 236.64 |
InChI | InChI=1/C6H12F2N2O2.ClH/c7-4(8)6(10,5(11)12)2-1-3-9;/h4H,1-3,9-10H2,(H,11,12);1H |
熔点 | >210°C (dec.) |
溶解度 | 溶于水 (高达25 mg/ml)。 |
存储条件 | Inert atmosphere,2-8°C |
稳定性 | 从提供的购买之日起稳定2年。蒸馏水中的溶液可以在-20 ° 下储存长达3个月。 |
外观 | 白色粉末 |
颜色 | White |
Merck | 14,3522 |
体外研究 | 用α-difluoromethyl-Orn处理BY2细胞,抑制其过氧化氢的产生,但并没有发生程序性细胞死亡。 |
体内研究 | Eflornithine is the only new molecule registered for the treatment of human African trypanosomiasis over the last 50 years. It is the drug used mainly as a back-up for melarsoprol refractory Trypanosoma brucei gambiense cases. In subjects with excessive, unwanted facial hair, eflornithine 15% cream is superior to placebo in reducing hair growth. After 24 weeks' treatment, 58% of eflornithine and 34% of placebo subjects have at least some improvement in facial hirsutism. The hair growth inhibitory activity of eflornithine is significantly enhanced when the eflornithine cream is applied onto a mouse skin area pretreated with microneedles. Treatment of coarctation hypertensive rats with eflornithine results in a normalization of the contractile intensity to KCI and norepinephrine and relaxations to acetylcholine by 14 days of hypertension. |
RTECS | RM2981900 |
海关编号 | 2922493800 |