中文名 | 汉防己甲素 |
英文名 | (S,S)-(+)-tetrandrine |
别名 | 特船君 粉防己碱 倒地拱素 汉防己碱 汉防己甲素 汉防己甲素, 来源于粉防己 TETRANDRINE 粉防己碱 标准品 |
英文别名 | Conba Jinake Trandrine Tetrandrin Tetrandrine D-Tetrandrine (+)-Tetrandrine (S,S)-(+)-tetrandrine TETRANDRINE, (S,S)-(+)-(RG) (1β)-6,6',7,12-tetramethoxy-2,2'-dimethylberbaman 6,6',7,12-Tetramethoxy-2,2'-dimethyl-1-beta-berbaman (1beta)-6,6',7,12-tetramethoxy-2,2'-dimethylberbaman (1beta,1'xi)-6,6',7,12-tetramethoxy-2,2'-dimethylberbaman Berbaman, 6,6',7,12-tetramethoxy-2,2'-dimethyl-, (1beta)- |
CAS | 518-34-3 |
EINECS | 683-095-7 |
化学式 | C38H42N2O6 |
分子量 | 622.75 |
InChI | InChI=1/C38H42N2O6/c1-39-15-13-25-20-32(42-4)34-22-28(25)29(39)17-23-7-10-27(11-8-23)45-33-19-24(9-12-31(33)41-3)18-30-36-26(14-16-40(30)2)21-35(43-5)37(44-6)38(36)46-34/h7-12,19-22,29-30H,13-18H2,1-6H3/t29?,30-/m0/s1 |
密度 | 1.1528 (rough estimate) |
熔点 | 219-222°C(lit.) |
沸点 | 662.81°C (rough estimate) |
比旋光度 | 285 º (c=1, CHCl3) |
闪点 | 175.8°C |
蒸汽压 | 4.88E-20mmHg at 25°C |
溶解度 | 氯仿 (微溶),甲醇 (微溶,加热) |
折射率 | 1.5300 (estimate) |
酸度系数 | 7.70±0.20(Predicted) |
存储条件 | 2-8°C |
外观 | 固体 |
颜色 | Off-White |
最大波长(λmax) | ['283nm(EtOH)(lit.)'] |
Merck | 14,9231 |
物化性质 | 来源于防己科植物粉防己根 |
MDL号 | MFCD08689909 |
危险品标志 | Xi - 刺激性物品 |
风险术语 | 36/37/38 - 刺激眼睛、呼吸系统和皮肤。 |
安全术语 | S22 - 切勿吸入粉尘。 S24/25 - 避免与皮肤和眼睛接触。 S36 - 穿戴适当的防护服。 S26 - 不慎与眼睛接触后,请立即用大量清水冲洗并征求医生意见。 |
WGK Germany | 3 |
RTECS | XE9350000 |
海关编号 | 29349990 |
参考资料 展开查看 | 1. 杨敬宁, 张燕, 王敏,等. 粉防己碱对胡蜂毒素致多器官功能障碍综合征大鼠的保护作用[J]. 中国工业医学杂志, 2018, 31(05):12-13+83. 2. 郭孝玉, 张潇月, 李奇勇,等. 粉防己碱对铜绿微囊藻的化感作用[J]. 三明学院学报, 2017, 034(006):57-61. 3. 张克清, 戴珍, 李彦萍. 粉防己碱激活Akt/GSK-3b信号通路保护心肌I/R大鼠研究[J]. 新中医, 2018, 050(009):12-17. 4. 胡筱希 朱荣 唐新 等. 响应曲面法优化防己中汉防己甲素及汉防己乙素的提取工艺[J]. 中国民族民间医药 2020 v.29;No.366(01):29-34. 5. 何婉婉 张建逵 李云静 康廷国.北豆根显微特征指数与化学成分相关性[J].中国实验方剂学杂志 2017 23(01):42-46. 6. 何婉婉 张建逵 李云静 康廷国.北豆根药材粉末色泽与有效成分的相关性[J].中国实验方剂学杂志 2017 23(05):57-62. 7. Mengjuan Jiang, Ruoshi Zhang, Yingli Wang, Wenna Jing, Ying Liu, Yan Ma, Bingjun Sun, Menglin Wang, Peizhuo Chen, Hongzhuo Liu, and Zhonggui He,Reduction-sensitive Paclitaxel Prodrug Self-assembled Nanoparticles with Tetrandrine Effectively Promote Synergi 8. Yang, Zhenzhong, et al. "Deciphering bioactive compounds of complex natural products by tandem mass spectral molecular networking combined with an aggregation-induced emission based probe." Journal of Pharmaceutical Analysis (2020).https://doi.org/10.1016/ 9. [IF=5.64] Wu Dousheng et al."Oleanolic Acid Induces the Type III Secretion System of Ralstonia solanacearum."Front Microbiol. 2015 Dec;0:1466 10. [IF=4.939] Mengjuan Jiang et al."Reduction-sensitive Paclitaxel Prodrug Self-assembled Nanoparticles with Tetrandrine Effectively Promote Synergistic Therapy Against Drug-sensitive and Multidrug-resistant Breast Cancer."Mol Pharmaceut. 2017;14(11):3628–3635 11. [IF=4.769] Zhenzhong Yang et al."Deciphering bioactive compounds of complex natural products by tandem mass spectral molecular networking combined with an aggregation-induced emission based probe."J Pharm Anal. 2020 Nov;: 12. [IF=4.411] Dan Liao et al."Tetrandrine Interaction with ABCB1 Reverses Multidrug Resistance in Cancer Cells Through Competition with Anti-Cancer Drugs Followed by Downregulation of ABCB1 Expression."Molecules. 2019 Jan;24(23):4383 13. [IF=3] Qu Lala et al."Phenotypic assessment and ligand screening of ETA/ETB receptors with label-free dynamic mass redistribution assay."N-S Arch Pharmacol. 2020 Jun;393(6):937-950 |
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