中文名 | 2-甲基-5-硝基-N,N-二甲基苯磺酰胺 |
英文名 | N,N,2-trimethyl-5-nitrobenzenesulfonamide |
别名 | 化合物BRL 50481 N,N,2-三甲基-5-硝基苯磺酰胺 2-甲基-5-硝基-N,N-二甲基苯磺酰胺 |
英文别名 | -50481 BRL 50481 N,N,2-trimethyl-5-nitrobenzenesulfonamide N,N,2-Trimethyl-5-nitrobenzenesulfonamide 5-NITRO-2,N,N-TRIMETHYLBENZENESULFONAMIDE N,N,2-trimethyl-5-nitro-benzenesulfonamide N,N,2-TRIMETHYL-5-NITRO-BENZENESULFONAMIDE Benzenesulfonamide, N,N,2-trimethyl-5-nitro- 3-(N,N-Dimethylsulfonamido)-4-methylnitrobenzene,5-Nitro-2-N,N-trimethylbenzenesulfonamide |
CAS | 433695-36-4 |
EINECS | 1592732-453-0 |
化学式 | C9H12N2O4S |
分子量 | 244.27 |
InChI | InChI=1/C9H12N2O4S/c1-7-4-5-8(11(12)13)6-9(7)16(14,15)10(2)3/h4-6H,1-3H3 |
密度 | 1.334±0.06 g/cm3(Predicted) |
熔点 | 65-67°C |
沸点 | 391.1±52.0 °C(Predicted) |
闪点 | 190.4°C |
蒸汽压 | 2.52E-06mmHg at 25°C |
溶解度 | DMSO: 12 mg/mL |
折射率 | 1.561 |
酸度系数 | -5?+-.0.70(Predicted) |
存储条件 | 2-8°C |
稳定性 | 从提供的购买之日起稳定2年。在DMSO或乙醇中的溶液可以在-20 ° 储存长达3个月。 |
外观 | 固体 |
颜色 | white |
体外研究 | BRL-50481 increases the cAMP content (19.1±6.2% of IBMX response at 300 μM) but is considerably less potent. BRL-50481 (30 μM) fails to suppress proliferation by itself but significantly potentiates the effect of rolipram. BRL-50481 (30 μM) has no effect on IL-15-induced proliferation but augments the inhibitory effect of rolipram. Pretreatment (30 min) of human monocytes with BRL-50481 has, by itself, a negligible (~2 to 10%) inhibitory effect on TNFα output at all concentrations tested. BRL-50481 also potentiates the inhibitory effect of PGE 2 on LPS-induced TNFα release. BRL-50481 has no significant effect by itself on κB-dependent transcription (5.6±1.9% inhibition at 30 μM) and fails to enhance the effect of rolipram (maximum inhibition, 52.9±2.7%; pIC 30 value of 5.33±0.12). BRL-50481 suppresses, in a concentration-dependent manner, LPS-induced TNFα release in monocytes in which PDE7A1 is induced (21.7±1.6% inhibition at 30 μM at the 12-h time point). |
WGK Germany | 3 |
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