中文名 | NSC 663284 |
英文名 | NSC 663284 |
别名 | 化合物 T16357 |
英文别名 | NSC 663284 CDC25 Phosphatase Inhibitor II, NSC 663284 5,8-Quinolinedione, 6-chloro-7-[[2-(4-morpholinyl)ethyl]amino]- |
CAS | 383907-43-5 |
化学式 | C15H16ClN3O3 |
分子量 | 321.76 |
密度 | 1.41±0.1 g/cm3(Predicted) |
沸点 | 478.8±45.0 °C(Predicted) |
溶解度 | DMSO: 16 mg/mL |
酸度系数 | 6.79±0.10(Predicted) |
存储条件 | 2-8°C |
稳定性 | 从提供的购买之日起稳定2年。在DMSO或乙醇中的溶液可以在-20 ° 储存长达1个月。 |
敏感性 | Light Sensitive |
外观 | 固体 |
颜色 | red |
体外研究 | NSC 663284 (3-100μM; 48 hours) has a mean IC 50 value in the NCI 60 Cell human tumor panel of 1.5 ± 0.6 μM, has IC 50 values of 0.2 μM in human breast cancer MDA-MB-435 and MDA-N cells, has an IC 50 value of 1.7 μM in human breast MCF-7 cells in culture. NSC 663284 has relative IC 50 values for Cdc25B2 (IC 50 =0.21 μM) are 20- and 450-fold lower than for VHR (IC 50 =4.0 μM) or PTP1B (IC 50 >4.0 μM), respectively. |
体内研究 | NSC 663284 (intravenous injection; 2, 3, and 5mg/kg) inhibits the growth of subcutaneous human colon HT29 xenografts in SCID mice. After a single dose of 5 mg/kg, NSC 663284 is not detectable in plasma or tissues beyond 5 min. Following NSC 663284 treatment of tumor-bearing SCID mice, reduces glutathione concentrations in HT29 tumor are decreased to a greater extent and remained decreased for longer than the reduced glutathione concentrations in liver and kidneys. |
危险品标志 | Xi - 刺激性物品 |
风险术语 | 36/37/38 - 刺激眼睛、呼吸系统和皮肤。 |
安全术语 | 26 - 不慎与眼睛接触后,请立即用大量清水冲洗并征求医生意见。 |
WGK Germany | 3 |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 3.108 ml | 15.54 ml | 31.079 ml |
5 mM | 0.622 ml | 3.108 ml | 6.216 ml |
10 mM | 0.311 ml | 1.554 ml | 3.108 ml |
5 mM | 0.062 ml | 0.311 ml | 0.622 ml |