中文名 | 20-去氧巨大戟萜醇 |
英文名 | 20-deoxyingenol |
别名 | 20-去氧巨大戟醇 20-脱氧巨大戟萜醇 20-脱氧-巨大戟醇 20-去氧巨大戟萜醇 |
英文别名 | 20-deoxyingenol 20-DEOXYINGENOL 20-deoxyingenol 54706-99-9 (1aR,10aα)-1a,2,5,5a,6,9,10,10a-Octahydro-5β,5aβ,6β-trihydroxy-1,1,4,7,9α-pentamethyl-1H-2α,8aα-methanocyclopenta[a]cyclopropa[e]cyclodecen-11-one 1H-2,8a-Methanocyclopenta[a]cyclopropa[e]cyclodecen-11-one, 1a,2,5,5a,6,9,10,10a-octahydro-5,5a,6-trihydroxy-1,1,4,7,9-pentamethyl-, (1aR,2S,5R,5aS,6S,8aS,9R,10aR)- |
CAS | 54706-99-9 |
EINECS | 2017-001-1 |
化学式 | C20H28O4 |
分子量 | 332.43 |
密度 | 1.26±0.1 g/cm3 (20 ºC 760 Torr) |
熔点 | 208-209℃(Decomposition) |
沸点 | 470.5±45.0 °C(Predicted) |
溶解度 | DMSO: 50毫克/毫升 (150.41毫米; 需要超声波);H2O: <0.1毫克/毫升 (不溶) |
酸度系数 | 12.21±0.70(Predicted) |
存储条件 | 2-8℃ |
外观 | 粉末 |
体外研究 | 20-Deoxyingenol (2.5-10 mM; 24 h) protects chondrocytes against Tert-butyl hydroperoxide solution (TBHP; 100 μM)-induced cell death. 20-Deoxyingenol (5-10 mM) decreases the TBHP-induced upregulation of apoptosis protein cleaved-caspase3 and the senescence protein p16INK4a in chondrocytes. 20-Deoxyingenol (2.5-40 mM; 24 h) has no cytotoxic effect on chondrocytes at the concentration less than 10 mM. 20-Deoxyingenol (10 mM; 24 h) restores autophagy flux in TBHP treated chondrocytes. 20-Deoxyingenol (4-10 mM; 24 h) promotes the nuclear level of TFEB in TBHP treated chondrocytes. |
上游原料 | 三氟甲磺酸酐 |
下游产品 | 巨大戟醇 |