中文名 | 二氢卟吩E6 |
英文名 | CHLORIN E6 |
别名 | 二氢卟吩 二氢卟吩E6 氯E6三钠盐 叶绿素杂质11 (7S,8S)-7-(2-羧乙基)-5-(羧甲基)-18-乙基-2,8,12,17-四甲基-13-乙烯基-7H,8H-卟啉-3-羧酸 (2S-反式)-18-羧基-20-(羧甲基)-13-乙基-2,3-二氢3,7,12,17-四甲基-8-乙烯基-21H,23H-卟吩-2-丙酸 二氢卟吩E6|(2S-反式)8-羧基-20-(羧甲基)-13-乙基-2,3-氢3,7,12,17-四甲基- 8-乙烯基-21H,23H-卟吩-2-丙酸 |
英文别名 | CHLORIN E6 PHYTOCHLORIN Chlorophyll Impurity 11 12,17-tetramethyl-3-dihydro-(2s-trans)-thyl-7 21h,23h-porphine-2-propanoicacid,18-carboxy-20-(carboxymethyl)-8-ethenyl-13-e |
CAS | 19660-77-6 |
EINECS | 243-209-4 |
化学式 | C34H36N4O6 |
分子量 | 596.673 |
密度 | 1.306±0.06 g/cm3(Predicted) |
沸点 | 1093.7±60.0 °C(Predicted) |
存储条件 | 2-8℃ |
产品用途 | 用途是以天然叶绿素为原料,通过现代科技手段精制、提炼和修饰而得的叶绿素降解产物,是一种性能优良的光敏剂。与目前报导和使用的血卟啉醚类(HPD)、光敏素Ⅱ(photofrinⅡ)等卟啉类光敏剂相比,具有分子结构明确、红外区吸收系数大、光动力反应能力强以及毒副作用小等优诸多点,因此正在发展成为新一代理想的光动力治癌药物。 |
参考资料 展开查看 | 1. [IF=13.281] Xiaobing Chen et al."Delivery of siHIF-1α to Reconstruct Tumor Normoxic Microenvironment for Effective Chemotherapeutic and Photodynamic Anticancer Treatments."Small. 2021 Jun;17(25):2100609 2. [IF=11.556] Wei Qiu et al."Polyamino acid calcified nanohybrids induce immunogenic cell death for augmented chemotherapy and chemo-photodynamic synergistic therapy."Theranostics. 2021; 11(19): 9652–9666 3. [IF=9.229] Binlong Chen et al."Precise Monitoring of Singlet Oxygen in Specific Endocytic Organelles by Super-pH-Resolved Nanosensors."Acs Appl Mater Inter. 2021;13(16):18533–18544 4. [IF=8.758] Huan Wu et al."Synthesis of a Clay-Based Nanoagent for Photonanomedicine."Acs Appl Mater Inter. 2020;12(1):390–399 5. [IF=8.198] Yong-E Gao et al."Silk Sericin-Based Nanoparticle as the Photosensitizer Chlorin e6 Carrier for Enhanced Cancer Photodynamic Therapy."Acs Sustain Chem Eng. 2021;9(8):3213–3222 6. [IF=7.79] Shanshan Fan et al."Manganese/iron-based nanoprobes for photodynamic/chemotherapy combination therapy of tumor guided by multimodal imaging."Nanoscale. 2021 Mar;13(10):5383-5399 7. [IF=6.331] Tianren Xu et al."Defective transition metal hydroxide-based nanoagents with hypoxia relief for photothermal-enhanced photodynamic therapy."J Mater Chem B. 2021 Feb;9(4):1018-1029 8. [IF=6.331] Liqun Dai et al."PSMA-targeted melanin-like nanoparticles as a multifunctional nanoplatform for prostate cancer theranostics."J Mater Chem B. 2021 Feb;9(4):1151-1161 9. [IF=6.183] Qian Xie et al."Hybrid-cell membrane-coated nanocomplex-loaded chikusetsusaponin IVa methyl ester for a combinational therapy against breast cancer assisted by Ce6."Biomater Sci-Uk. 2021 Apr;9(8):2991-3004 10. [IF=4.914] Shuting Wang et al."Bacterial infection microenvironment sensitive prodrug micelles with enhanced photodynamic activities for infection control."Colloid Interfac Sci. 2021 Jan;40:100354 11. [IF=4.389] Nian Liu et al."Polyphotosensitizer nanogels for GSH-responsive histone deacetylase inhibitors delivery and enhanced cancer photodynamic therapy."Colloid Surface B. 2020 Apr;188:110753 12. [IF=10.041] Ying Li et al."Palliating the escalated post-PDT tumor hypoxia with a dual cascade oxygenation nanocomplex."Appl Mater Today. 2022 Mar;26:101287 13. [IF=10.435] Wu Kai et al."Urchin-like magnetic microspheres for cancer therapy through synergistic effect of mechanical force, photothermal and photodynamic effects."JOURNAL OF NANOBIOTECHNOLOGY. 2022 Dec;20(1):1-22 14. [IF=9.776] Mian Yu et al."Oxidative stress-amplified nanomedicine for intensified ferroptosis-apoptosis combined tumor therapy."JOURNAL OF CONTROLLED RELEASE. 2022 Jul;347:104 15. [IF=15.589] Yunfei Yi et al."Transforming “cold” tumors into “hot” ones via tumor-microenvironment-responsive siRNA micelleplexes for enhanced immunotherapy."Matter. 2022 May;: |
摘要:
由蚕沙叶绿素粗品,经酸碱降解反应制得二氢卟吩e6(I);并测定了1在D2O中对NADPH光氧化作用的敏化效应和对小鼠S180肉瘤的光动力损伤作用.初步试验结果表明:1在非细胞体系内的光敏化力和对小鼠S180肉瘤的光动力疗效均优于参比药物血卟啉衍生物(HPD).
关键词:
DOI:
10.3969/j.issn.1001-8255.2000.05.009
被引量:
年份:
2000
摘要:
选择脱镁叶绿酸-a甲酯为起始原料,经过化学结构修饰转换成其他 叶绿素-a衍生物.以过氧化氢/盐酸,N-氯代丁二酰亚胺(NCS),氯化氢(或者浓盐酸)为氯化剂,根据3-乙烯基和20-meso-位的不同化学反应 活性,通过亲电加成和亲电取代反应,在二氢卟吩环上选择性地引进氯原子,完成8种未见报道的具有叶绿素-a基本碳架的氯代二氢卟吩衍生物的合成.所合成的 新化合物均经UV,IR,1H NMR及元素分析证明其结构.
关键词:
脱镁叶绿酸-a甲酯 亲电反应 选择性氯代 氯代二氢卟吩 光动力治疗
DOI:
CNKI:SUN:YJHU.0.2009-10-015
被引量:
年份:
2009
摘要:
应用二氢卟吩e6作为声敏剂, 通过超声波激活, 研究其对乳腺癌细胞MDA-MB-231生长的作用.超声与二氢卟吩e6单独及联合处理MDA-MB-231细胞和正常人外周血单核细胞(peripheral mononuclear cell, PMNC)45 min后, 采用MTT比色法检测细胞生长, 荧光倒置显微镜下观察细胞形态.频率1.0 MHz,超声强度1.0~2.0 W/cm作用60 s呈强度依赖性抑制PMNC和MDA-MB-231细胞的生长, 其抑制50%PMNC和MDA-MB-231细胞生长的超声强度分别为1.23 W/cm和1.25 W/cm, 差异无统计学意义(>0.05); 0.10~1.60 mg/mL二氢卟吩e6呈浓度依赖性地抑制PMNC和MDA-MB-231细胞生长, 其抑制PMNC和MDA-MB-231细胞生长的IC值分别为0.77 mg/mL和0.38 mg/mL, 差异有统计学意义(<0.05).频率1.0 MHz和超声强度0.5 W/cm作用60 s以及0.05~0.20 mg/mL二氢卟吩e6作用两者联合未明显抑制PMNC细胞的生长(>0.05), 但明显抑制MDA-MB-231细胞的生长(<0.05).细胞形态学观察结果显示, 与单纯超声(1.0 MHz频率,0.5 W/cm声强作用60 s)及单纯二氢卟吩e6(0.20 mg/mL)作用相比, 超声联合二氢卟吩e6组的MDA-MB-231细胞死亡率显著增加(<0.05).超声联合二氢卟吩e6声动力能够特异性抑制乳腺癌MDA-MB-231细胞生长, 二氢卟吩e6有望成为一种新型声敏剂应用于乳腺癌的声动力治疗.
收起
年份:
2010
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