中文名 | 阿尼芬净 |
英文名 | Anidulafungin |
别名 | 阿尼芬净 阿尼分净 安多拉芬净 阿尼芬净杂质 阿尼杜拉芬金杂质 阿尼芬净[干冰运输] ANIDULAFUNGIN阿尼芬净 |
英文别名 | Eraxis Ecalta LY 303366 Anidulafungin LY 303366, Eraxis Anidulafungin(LY303366) 1-[(4R,5R)-4,5-dihydroxy-N2-[[4''-(pentyloxy)[1,1'',1''-terphenyl]-4-yl]carbonyl]-L-ornithine]-echinocandin B |
CAS | 166663-25-8 |
EINECS | 658-060-4 |
化学式 | C58H73N7O17 |
分子量 | 1140.24 |
InChI | InChI=1/C58H73N7O17/c1-5-6-7-24-82-40-22-18-35(19-23-40)33-10-8-32(9-11-33)34-12-14-37(15-13-34)51(74)59-41-26-43(70)54(77)63-56(79)47-48(71)29(2)27-65(47)58(81)45(31(4)67)61-55(78)46(50(73)49(72)36-16-20-38(68)21-17-36)62-53(76)42-25-39(69)28-64(42)57(80)44(30(3)66)60-52(41)75/h8-23,29-31,39,41-50,54,66-73,77H,5-7,24-28H2,1-4H3,(H,59,74)(H,60,75)(H,61,78)(H,62,76)(H,63,79)/t29-,30+,31+,39+,41-,42-,43+,44-,45-,46-,47-,48-,49-,50-,54+/m0/s1 |
密度 | 1.47±0.1 g/cm3(Predicted) |
熔点 | >196°C (subl.) |
沸点 | 1477.0±65.0 °C(Predicted) |
闪点 | 847°C |
蒸汽压 | 0mmHg at 25°C |
溶解度 | DMSO (微溶,加热),甲醇 (微溶) |
折射率 | 1.688 |
酸度系数 | 9.86±0.26(Predicted) |
存储条件 | under inert gas (nitrogen or Argon) at 2-8°C |
外观 | 固体 |
颜色 | White to Pale Beige |
靶点 | glucan synthase;Antifungal |
参考资料 展开查看 | 1: Hinske LC, Weis F, Heyn J, Hinske P, Beiras-Fernandez A. The role of micafungin and anidulafungin in the treatment of systemic fungal infections: applications and patents for two novel echinocandins. Recent Pat Antiinfect Drug Discov. 2012 Apr;7(1):1-7. Review. PubMed PMID: 22044354. 2: George J, Reboli AC. Anidulafungin: when and how? The clinician's view. Mycoses. 2012 Jan;55(1):36-44. doi: 10.1111/j.1439-0507.2011.02052.x. Epub 2011 Jun 13. Review. PubMed PMID: 21668526. 3: Wilke M. Treatment and prophylaxis of invasive candidiasis with anidulafungin, caspofungin and micafungin and its impact on use and costs: review of the literature. Eur J Med Res. 2011 Apr 28;16(4):180-6. Review. PubMed PMID: 21486732; PubMed Central PMCID: PMC3352074. 4: Glöckner A. Treatment and prophylaxis of invasive candidiasis with anidulafungin, caspofungin and micafungin:review of the literature. Eur J Med Res. 2011 Apr 28;16(4):167-79. Review. PubMed PMID: 21486731; PubMed Central PMCID: PMC3352073. 5: Kofla G, Ruhnke M. Pharmacology and metabolism of anidulafungin, caspofungin and micafungin in the treatment of invasive candidosis: review of the literature. Eur J Med Res. 2011 Apr 28;16(4):159-66. Review. PubMed PMID: 21486730; PubMed Central PMCID: PMC3352072. 6: Tapısız A. Anidulafungin: is it a promising option in the treatment of pediatric invasive fungal infections? Expert Rev Anti Infect Ther. 2011 Mar;9(3):339-46. doi: 10.1586/eri.11.7. Review. PubMed PMID: 21417873. 7: Mayr A, Aigner M, L |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 0.877 ml | 4.385 ml | 8.77 ml |
5 mM | 0.175 ml | 0.877 ml | 1.754 ml |
10 mM | 0.088 ml | 0.439 ml | 0.877 ml |
5 mM | 0.018 ml | 0.088 ml | 0.175 ml |