中文名 | 内皮素2 |
英文名 | endothelin 2 |
别名 | 内皮素2 人内皮素-2 |
英文别名 | endothelin 2 ET-2 (HUMAN) ENDOTHELIN 2 ENDOTHELIN 2 HUMAN ENDOTHELIN-II, HUMAN ET-2 (HUMAN, PIG, DOG) ENDOTHELIN-2 (HUMAN, CANINE) H-Cys-Ser-Cys-Ser-Ser-Trp-Leu-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-Oh H-CYS-SER-CYS-SER-SER-TRP-LEU-ASP-LYS-GLU-CYS-VAL-TYR-PHE-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH |
CAS | 123562-20-9 |
化学式 | C115H160N26O32S4 |
分子量 | 2546.92 |
存储条件 | −20°C |
外观 | 粉末 |
颜色 | white |
MDL号 | MFCD00133306 |
体外研究 | At nanomolar concentrations, Endothelin-2 exhibits a strong and long-lasting vasoconstrictor activity characteristic of endothelin (EC 50 =0.52 nM). Endothelin-2 is a chemoattractant for macrophages and THP-1 monocytic cells, but not for freshly isolated monocytes. The chemotactic response to Endothelin-2 shows a typical bell-shaped response curve. Experiments with endothelin receptor antagonists shows that migration to Endothelin-2 is mediated via the ET-RB receptor. Endothelin-2 expression by tumors may modulate the behavior of macrophages such that activated cells accumulate in areas of hypoxia. |
体内研究 | Two distinct phases of pressor effects are typically seen in response to Endothelin-2: the early phase immediately follows the depressor response and dominates during the next 3-10 min, whereas the late pressor effect develops 10-20 min after the injection and lasts >1 hr. |
危险品标志 | T+ - 极高毒性物品 |
风险术语 | 26/27/28 - 吸入、皮肤接触及吞食有极高毒性。 |
安全术语 | S28 - 不慎与皮肤接触后,立即用大量肥皂水冲洗。 S36/37 - 穿戴适当的防护服和手套。 S45 - 若发生事故或感不适,立即就医(可能的话,出示其标签)。 |
危险品运输编号 | UN 2811 6.1/PG 1 |
WGK Germany | 3 |
FLUKA BRAND F CODES | 3-10 |
Hazard Class | 6.1 |