中文名 | 11-羰基-beta-乙酰乳香酸 |
英文名 | (3alpha)-3-(acetyloxy)-11-oxours-12-en-24-oic acid |
别名 | 11-羰基-B-乙酰乳香酸 乙酰基-11酮-Β-乳香酸 11-羰基-Β-乙酰乳香酸 乙酰基-11-酮基-Β-乳香酸 11-羰基-beta-乙酰乳香酸 11-羰基-Β-乙酰乳香酸标准品 3-O-乙酰基 11-酮-Β-乳香酸 3-乙酰基-11-酮基-Β-乳香脂酸, 来源于卡氏乳香树 |
英文别名 | AKBA AK-BETABA BOSWELLIC ACID, ACETYL KETO ACETYL-11-KETO-B-BOSWELLIC ACID, 3 ACETYL-11-KETO-BETA-BOSWELLIC ACID Acetyl-11-keto-beta-boswellic acid 3-ACETYL-11-KETO-BETA-BOSWELLIC ACID 3-Acetyl-11-keto-beta-boswellic acid 3-O-ACETYL-11-KETO-BETA-BOSWELLIC ACID (3α)-3-Acetoxy-11-oxours-12-en-24-oic acid 3-ACETYL-11-KETONE-BETA-ACETYLBOSWELLIC ACID (3α)-3-(acetyloxy)-11-oxours-12-en-24-oic acid (3alpha)-3-(acetyloxy)-11-oxours-12-en-24-oic acid urs-12-en-24-oic acid, 3-(acetyloxy)-11-oxo-, (3α)- |
CAS | 67416-61-9 |
化学式 | C32H48O5 |
分子量 | 512.73 |
InChI | InChI=1/C32H48O5/c1-18-9-12-28(4)15-16-30(6)21(25(28)19(18)2)17-22(34)26-29(5)13-11-24(37-20(3)33)32(8,27(35)36)23(29)10-14-31(26,30)7/h17-19,23-26H,9-16H2,1-8H3,(H,35,36)/t18-,19+,23-,24-,25+,26-,28-,29+,30-,31-,32-/m1/s1 |
密度 | 1.13±0.1 g/cm3(Predicted) |
熔点 | 271℃ |
沸点 | 600.3±55.0 °C(Predicted) |
比旋光度 | (c, 4.2 in CHCl3)+87.3 |
闪点 | 184.4°C |
蒸汽压 | 5.85E-16mmHg at 25°C |
溶解度 | 氯仿 (微溶),甲醇 (微溶) |
折射率 | 1.549 |
酸度系数 | 4.28±0.70(Predicted) |
存储条件 | Sealed in dry,Store in freezer, under -20°C |
外观 | 整洁 |
颜色 | White to Off-White |
MDL号 | MFCD03788777 |
体外研究 | AKBA (Acetyl-11-keto-β-boswellic acid) significantly reduced infarct volumes and apoptotic cells, and also increased neurologic scores by elevating the Nrf2 and HO-1 expression in brain tissues in middle cerebral artery occlusion (MCAO) rats at 48 hours post reperfusion. In primary cultured neurons, AKBA increased the Nrf2 and HO-1 expression, which provided protection against OGD-induced oxidative insult. Additionally, AKBA treatment increased Nrf2 binding activity to antioxidant-response elements (ARE). AKBA (Acetyl-11-keto-β-boswellic acid) significantly inhibited human colon adenocarcinoma growth, showing arrest of the cell cycle in G1-phase and induction of apoptosis. AKBA (Acetyl-11-keto-β-boswellic acid) triggered significant lipolysis in 3T3-L1 adipocytes as shown by reduced neutral lipids in cytosol and increased free fatty acids in culture medium. Increased lipolysis by AKBA was accompanied by up-regulation of lipolytic enzymes, adipocyte triglyceride lipase (ATGL) and hormone sensitive lipase (HSL), and a decreased expression of lipid droplet stability regulator perilipin. In addition, AKBA (Acetyl-11-keto-β-boswellic acid) treatment reduced phenotypic markers of mature adipocyte aP2, adiponectin and glut-4 in mature adipocytes. |
体内研究 | AKBA (Acetyl-11-keto-β-boswellic acid) significantly prevented the formation of intestinal adenomatous polyps without toxicity to mice. AKBA's activity both in the prevention of small intestinal and colonic polyps was more potently than aspirin. Histopathologic examination revealed that AKBA's effect, that is the reduction of polyp size and degree of dysplasia, was more prominent in larger sized polyps, especially those originating in colon. AKBA (Acetyl-11-keto-β-boswellic acid) administration in mice effectively delayed the growth of HT-29 xenografts without signs of toxicity. The activity of AKBA was more potent than that of aspirin. AKBA (Acetyl-11-keto-β-boswellic acid) exhibited anti-cancer activity in vitro and in vivo. With oral application in mice, AKBA significantly inhibited SGC-7901 and MKN-45 xenografts without toxicity. |
风险术语 | 36/37/38 - 刺激眼睛、呼吸系统和皮肤。 |
安全术语 | 26 - 不慎与眼睛接触后,请立即用大量清水冲洗并征求医生意见。 |
WGK Germany | 3 |
海关编号 | 2918300000 |
参考资料 展开查看 | 1. Ruixue Chen, Guijuan Zhang, Yi Ma, Fengjie Bie, Hongxia Fan, Min Ma, "Pharmacodynamics and Medicinal Chemistry of an External Chinese Herbal Formula for Mammary Precancerous Lesions", Evidence-Based Complementary and Alternative Medicine, vol. 2017, Articl |
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