中文名 | 硫酸阿米卡星 |
英文名 | amikacin sulfate |
别名 | 硫酸阿米卡星 阿米卡霉素硫酸 磺胺甲恶唑149022-22-0 硫酸阿米卡星149022-22-0 |
英文别名 | AMIKASIN SULFATE liusuanamukaxonm amikacin sulfate Amikacin Sulfate Salt Amikacin sulfate salt mikacin disulfate salt AMIKACIN SULFATE SALT, AMINOGLYCOSID (2R)-4-amino-N-{(1R,2S,3S,4R,5S)-5-amino-2-[(3-amino-3-deoxy-α-D-glucopyranosyl)oxy]-4-[(6-amino-6-deoxy-α-D-glucopyranosyl)oxy]-3-hydroxycyclohexyl}-2-hydroxybutanamide sulfate (salt) |
CAS | 149022-22-0 |
EINECS | 254-648-6 |
化学式 | C22H45N5O17S |
分子量 | 683.68 |
InChI | InChI=1/C22H43N5O13.H2O4S/c23-2-1-8(29)20(36)27-7-3-6(25)18(39-22-16(34)15(33)13(31)9(4-24)37-22)17(35)19(7)40-21-14(32)11(26)12(30)10(5-28)38-21;1-5(2,3)4/h6-19,21-22,28-35H,1-5,23-26H2,(H,27,36);(H2,1,2,3,4)/t6-,7+,8+,9+,10+,11-,12+,13+,14+,15-,16+,17-,18+,19-,21+,22+;/m0./s1 |
InChIKey | HIBICIOPDUTNRR-BOEHXBESSA-N |
熔点 | 220-230℃ |
沸点 | 1102.4°C at 760 mmHg |
闪点 | 620.5°C |
蒸汽压 | 0mmHg at 25°C |
溶解度 | H2O: 可溶物50mg/mL |
存储条件 | Inert atmosphere,2-8°C |
外观 | 固体 |
颜色 | white to off-white |
MDL号 | MFCD00167475 |
体外研究 | Amikacin offers definite advantages for treating infections caused by organisms resistant to other aminoglycosides. Amikaci is affected by relatively few arninoglycoside-modifying enzymes. Amikacin is useful in the treatment of infections caused by Nocardia asteroides , Mycobacterium avium-intracellulare , and certain species of "rapid-growing" mycobacteria (that is, M. chelonae and M. fortuitumi ). Amikacin (100-1500 μM) causes a reliable dose-dependent loss of lateral line zebrafish hair cells with a LD 50 value of 453 μM. |
WGK Germany | 2 |
RTECS | WK1961200 |
上游原料 | 丙酮 硫酸 |
参考资料 展开查看 | 1. 高铭坤, 张智, 钱芳. 混合菌制剂(BMX)毒理,功能性试验及对育肥猪的作用效果[J]. 饲料研究, 2018, No.485(04):66-71. 2. 刘敏芳, 曹梦蕊, 李荣旭,等. 广东部分地区水禽源沙门氏菌的分离鉴定与药物敏感性分析[J]. 黑龙江畜牧兽医, 2018(10). 3. 张济培, 韦庆兰, 谭华龙,等. 广东水禽源大肠埃希菌耐药性及氨基糖苷类耐药基因研究[J]. 动物医学进展, 2016, 37(005):42-46. 4. 韦庆兰, 张济培, 任涛,等. 广东地区水禽源大肠杆菌药物敏感性分析[J]. 黑龙江畜牧兽医, 2015, 000(012):180-181. 5. [IF=7.514] Ximo Wang et al."A novel SERS sensor for the ultrasensitive detection of kanamycin based on a Zn-doped carbon quantum dot catalytic switch controlled by nucleic acid aptamer and size-controlled gold nanorods."Food Chem. 2021 Nov;362:130261 6. [IF=2.281] Zhiqiang Zhang et al."Contribution of the colicin receptor CirA to biofilm formation, antibotic resistance, and pathogenicity of Salmonella Enteritidis."J Basic Microb. 2020 Jan;60(1):72-81 |
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