蟾毒灵, 来源于蟾酥
蟾毒灵(bufalin)
CAS: 465-21-4;68403-26-8
化学式: C24H34O4
| 中文名 | 蟾毒灵 |
| 英文名 | bufalin |
| 别名 | 蟾蜍靈 蟾毒素 蟾毒灵 蟾酥灵 蟾毒精 蟾酥灵(标准品) 蟾毒灵, 来源于蟾酥 蟾毒灵(蟾酥灵,蟾蜍灵) |
| 英文别名 | BUFALIN bufalin 3,14-dihydroxybufa-20,22-dienolide 22-dienolide,3-beta,14-dihydroxy-5-beta-bufa-2 3-BETA-14-DIHYDROXY-5-BETA-BUFA-20,22-DIENOLIDE BUFA-20,22-DIENOLIDE, 3,14-DIHYDROXY-, (3B,5B)- (3BETA,5BETA)-3,14-DIHYDROXYBUFA-20,22-DIENOLIDE 22-dienolide,3,14-dihydroxy-,(3-beta,5-beta)-bufa-2 (3beta,5beta,8xi,9xi)-3,14-dihydroxybufa-20,22-dienolide |
| CAS | 465-21-4 68403-26-8 |
| 化学式 | C24H34O4 |
| 分子量 | 386.52 |
| InChI | InChI=1/C24H34O4/c1-22-10-7-17(25)13-16(22)4-5-20-19(22)8-11-23(2)18(9-12-24(20,23)27)15-3-6-21(26)28-14-15/h3,6,14,16-20,25,27H,4-5,7-13H2,1-2H3/t16-,17+,18-,19?,20?,22+,23-,24+/m1/s1 |
| InChIKey | QEEBRPGZBVVINN-ONGIWDLKSA-N |
| 密度 | 1.226±0.06 g/cm3(Predicted) |
| 熔点 | 242-243° |
| 沸点 | 556.6±50.0 °C(Predicted) |
| 比旋光度 | D -20° |
| 闪点 | 189°C |
| 蒸汽压 | 1.05E-14mmHg at 25°C |
| 溶解度 | DMSO: 100毫克/毫升 (258.72毫米; 需要超声波) |
| 折射率 | 1.593 |
| 酸度系数 | 15.01±0.70(Predicted) |
| 存储条件 | 2-8°C |
| 外观 | 白色至灰白色固体 |
| 物化性质 | 来源于蟾蜍科动物如中华大蟾蜍Bufo bufo gargarizans Cantor 或黑眶蟾蜍 Bufo melanostictus Schneider 的干燥分泌物。 |
| MDL号 | MFCD00056525 |
| 危险品标志 | T+ - 极高毒性物品 |
| 风险术语 | 28 - 吞食有极高毒性。 |
| 安全术语 | S28 - 不慎与皮肤接触后，立即用大量肥皂水冲洗。 S36/37 - 穿戴适当的防护服和手套。 S45 - 若发生事故或感不适，立即就医(可能的话，出示其标签)。 |
| 危险品运输编号 | UN 3462 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | EI2962500 |
| 海关编号 | 29322090 |
| Hazard Class | 6.1(a) |
| Packing Group | II |
| 参考资料 展开查看 | 1. 丁妍 王小玲 柳慧 等. Bufalin促进人食管癌细胞ECA109凋亡的研究[J]. 食管外科电子杂志 2014(02):49-54. 2. 张玲玲 韩金薇 王晓琳 et al. Bufalin抑制食管癌TE13细胞迁移机制探讨[J]. 中华肿瘤防治杂志 2016 23(13):837-843. 3. 陈砚凝, 刘尧, 王小玲,等. 蟾蜍令灵对裸鼠食管鳞癌原位移植瘤中 P70S6K 表达的影响[J]. 中国全科医学, 2015(15期):1763-1767. 4. 丁妍,王小玲,邓会岩,苏丽宏,张培,刘月平.蟾蜍灵抑制Raf/MEK/细胞外信号调节激酶信号通路活化影响人食管鳞癌细胞增殖及迁移机制研究[J].中国全科医学,2015,18(21):2535-2541. 5. 田志辉, 张培, 曹彦坤,等. 蟾蜍灵抑制食管癌细胞增殖、迁移和趋化运动的机制研究[J]. 中国现代医学杂志, 2015(20):50-54. 6. 张妹砣 李玉桑 叶晓雪. 六神丸血浆药物化学的研究[J]. 绿色科技 2017 000(012):237-240. 7. 房蕴歌, 王鹏飞, 朱厚达,等. 蟾酥药材和饮片(蟾酥粉)的质量标准研究[J]. 中国中药杂志, 2020(8). 8. 曹月婷 崔可可 吴纪恒 等. 中华大蟾蜍毒液中蟾毒配基类成分的相关性研究[J]. 中国中药杂志 2019(9). 9. Liu, Yao, et al. "Effects of bufalin on the mTOR/p70S6K pathway and apoptosis in esophageal squamous cell carcinoma in nude mice." International journal of molecular medicine 40.2 (2017): 357-366. https://doi.org/10.3892/ijmm.2017.3039 10. Liu, Yao, et al. "Effects of bufalin on the mTOR/p70S6K pathway and apoptosis in esophageal squamous cell carcinoma in nude mice." International journal of molecular medicine 40.2 (2017): 357-366. https://doi.org/10.3892/ijmm.2017.3039 11. Song, Tao, et al. "Bufalin, a bufanolide steroid from the parotoid glands of the Chinese toad, suppresses hERG K+ currents expressed in HEK 293 cells." Fundamental & clinical pharmacology 31.6 (2017): 695-700.https://doi.org/10.1111/fcp.12306 12. Song, Tao, et al. "Bufalin, a bufanolide steroid from the parotoid glands of the Chinese toad, inhibits L‐type Ca2+ channels and contractility in rat ventricular myocytes." Fundamental & clinical pharmacology 31.3 (2017): 340-346.https://doi.org/10.1111/fc 13. Xie, Jinlin, et al. "Bufalin suppresses the proliferation and metastasis of renal cell carcinoma by inhibiting the PI3K/Akt/mTOR signaling pathway." Oncology letters 16.3 (2018): 3867-3873.https://doi.org/10.3892/ol.2018.9111 14. Haiyan Hu, Qi Qi, Ziyi Dong, Xianglong Yu, Yujia Mo, Juyuan Luo, Yan Wang, Shouying Du, Yang Lu,Albumin coated trimethyl chitosan-based targeting delivery platform for photothermal/chemo-synergistic cancer therapy,Carbohydrate Polymers,Volume 241,2020, 15. [IF=6.284] Lan Yu-Long et al."The sodium pump α1 subunit regulates bufalin sensitivity of human glioblastoma cells through the p53 signaling pathway."Cell Biol Toxicol. 2019 Dec;35(6):521-539 16. [IF=4.101] Yao Liu et al."Effects of bufalin on the mTOR/p70S6K pathway and apoptosis in esophageal squamous cell carcinoma in nude mice."Int J Mol Med. 2017 Aug;40(2):357-366 17. [IF=3.743] Yu-Long Lan et al."Bufalin inhibits glioblastoma growth by promoting proteasomal degradation of the Na+/K+-ATPase α1 subunit."Biomed Pharmacother. 2018 Jul;103:204 18. [IF=2.748] Tao Song et al."Bufalin, a bufanolide steroid from the parotoid glands of the Chinese toad, inhibits L-type Ca2+ channels and contractility in rat ventricular myocytes."Fund Clin Pharmacol. 2017 Jun;31(3):340-346 19. [IF=2.748] Tao Song et al."Bufalin, a bufanolide steroid from the parotoid glands of the Chinese toad, suppresses hERG K+ currents expressed in HEK293 cells."Fund Clin Pharmacol. 2017 Dec;31(6):695-700 20. [IF=2.311] Jinlin Xie et al."Bufalin suppresses the proliferation and metastasis of renal cell carcinoma by inhibiting the PI3K/Akt/mTOR signaling pathway."Oncol Lett. 2018 Sep;16(3):3867-3873 21. [IF=2.193] Zhang Mei-Tuo et al."Strategic Combination of Isocratic and Gradient Elution for Simultaneous Separation of Polar Compounds in Traditional Chinese Medicines by HPLC."J Anal Methods Chem. 2018;2018:7569283 22. [IF=9.381] Haiyan Hu et al."Albumin coated trimethyl chitosan-based targeting delivery platform for photothermal/chemo-synergistic cancer therapy."Carbohyd Polym. 2020 Aug;241:116335 23. [IF=4.411] Yueting Cao et al."Chemical Profile and Multicomponent Quantitative Analysis for the Quality Evaluation of Toad Venom from Different Origins."Molecules. 2019 Jan;24(19):3595 24. [IF=4.379] Cao Yueting et al."The impact of multiple climatic and geographic factors on the chemical defences of Asian toads (Bufo gargarizans Cantor)."Sci Rep-Uk. 2019 Nov;9(1):1-11 25. [IF=3.565] Liqiang Qian et al."Anti-tumor Activity of Bufalin by Inhibiting c-MET Mediated MEK/ERK and PI3K/AKT Signaling Pathways in Gallbladder Cancer."J Cancer. 2020; 11(11): 3114–3123 26. [IF=1.902] Ke-ke Cui et al."Quantitative analysis of multicomponents by a single marker and quality evaluation of Venenum Bufonis from different geographical origins."Biomed Chromatogr. 2019 Sep;33(9):e4555 |
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产品名: 蟾毒灵(10mM in DMSO,无菌) 去供应商网站查看 询盘CAS: IB03001
产地: 北京
包装: 1ml/瓶
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库存: 现询
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产品描述: 产品覆盖：小分子化合物、分析对照品、染色试剂、生化试剂盒、细胞生物学、分子生物学、抗体、蛋白、多肽、ELISA试剂盒、微生物培养、化学合成、仪器耗材、CRO技术 更多
提供多种规格现货供应
产品名: 蟾毒灵(10mM in DMSO,无菌) 去供应商网站查看 询盘CAS: IB03001
产地: 北京
包装: 1ml/瓶
规格: IB03001-1ml
价格: 电话、微信、QQ、邮件
库存: 现询
电话: 010-50973130
手机: 17801761073(微信同号)
电子邮件: 3193328036@qq.com
QQ: 3193328036
微信: 17801761073
产品描述: 产品覆盖：小分子化合物、分析对照品、染色试剂、生化试剂盒、细胞生物学、分子生物学、抗体、蛋白、多肽、ELISA试剂盒、微生物培养、化学合成、仪器耗材、CRO技术 更多
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