中文名 | Neomycin B Hexaacetate |
英文名 | Neomycin B Hexaacetate |
别名 | 新霉素B 新霉素溶液 新霉素标液 新霉素B六乙酸酯 化合物 T15348 硫酸弗兰西汀(新霉素B) |
英文别名 | actilin actiline NEOMYCIN B antibiotique NEOMYCIN STANDARD Neomycin solution Neomycin B Hexaacetate neomycine standard solution D-Streptamine, O-2,6-diamino-2,6-dideoxy-.beta.-L-idopyranosyl-(1?3)-O-.beta.-D-ribofuranosyl-(1?5)-O-2,6-diamino-2,6-dideoxy-.alpha.-D-glucopyranosyl-(1?4)-2-deoxy- |
CAS | 119-04-0 |
EINECS | 204-292-2 |
化学式 | C23H46N6O13 |
分子量 | 614.64 |
密度 | 1.3548 (rough estimate) |
熔点 | >194°C (dec.) |
沸点 | 658.4°C (rough estimate) |
溶解度 | 酸水溶液 (微溶) 、水 (微溶) |
折射率 | 1.6000 (estimate) |
酸度系数 | 12.93±0.70(Predicted) |
存储条件 | 2-8°C |
稳定性 | 吸湿性 |
外观 | 固体 |
颜色 | clear |
Merck | 13,6482 |
体外研究 | The inhibition of RNase P RNA cleavage by Framycetin (Neomycin B; Fradiomycin B) is sensitive to pH and an increase in pH suppresses the inhibition in other systems. Framycetin targets the bacterial and human ribosome and affect translation. 5″-azido neomycin B and Framycetin selectively inhibit production of the mature miRNA, boosts a downstream protein, and inhibits invasion in HCC cell line. Framycetin binds to a structural rather than a sequence motif of the RNA. Its primary cognate target is the decoding site of the 16S rRNA, but it also binds to the Rev-responsive element in HIV-1, group I introns, and the hammerhead ribozyme, and thus inhibits their biological function. Framycetin induces misreading of the genetic code during translation and inhibits several ribozymes. The ribosomal target site is the 16 S rRNA 1400 to 1500 region. |
危险品标志 | Xn - 有害物品 |
风险术语 | R42/43 - 吸入及皮肤接触可能致敏。 R63 - 可能有对胎儿造成伤害的危险。 R36/37/38 - 刺激眼睛、呼吸系统和皮肤。 |
安全术语 | S26 - 不慎与眼睛接触后,请立即用大量清水冲洗并征求医生意见。 S36/37/39 - 穿戴适当的防护服、手套和护目镜或面具。 S45 - 若发生事故或感不适,立即就医(可能的话,出示其标签)。 S36/37 - 穿戴适当的防护服和手套。 S23 - 切勿吸入蒸汽。 |
WGK Germany | 2 |
FLUKA BRAND F CODES | 8 |
下游产品 | 新霉素 |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 1.627 ml | 8.135 ml | 16.269 ml |
5 mM | 0.325 ml | 1.627 ml | 3.254 ml |
10 mM | 0.163 ml | 0.813 ml | 1.627 ml |
5 mM | 0.033 ml | 0.163 ml | 0.325 ml |
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