帕氟沙星
司氟沙星(Sparfloxacin)
CAS: 111542-93-9
化学式: C19H22F2N4O3
| 中文名 | 司氟沙星 |
| 英文名 | Sparfloxacin |
| 别名 | 司巴乐 海正立特 帕氟沙星 斯帕沙星 司巴沙星 司氟沙星 司帕沙星 5-氨基-1-环丙基-7-(3,5-二甲基-1-哌嗪基)-6,8-二氟-1,4-二氢-4-氧代喹啉-3-羧酸 5-氨基-1-环丙基-7-(顺式-3,5-二甲基-1-哌嗪基)-6,8-二氟-1,4-二氢-4-氧-哇啉-3-羟酸 |
| 英文别名 | CI-978 AT-4140 PD-131501 PD-131501 Sparfloxacin SparfloxacinHCl Sparfloxacinhydrochloride 5-amino-1-cyclopropyl-7-[(3S,5R)-3,5-dimethyl-1-piperazinyl]-6,8-difluoro-4-oxo-3-quinolinecarboxylic acid 5-Amino-1-cyclopropyl-7-(3,5-dimethyl-1-piperazinyl)-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid 3-Quinolinecarboxylic acid, 5-amino-1-cyclopropyl-7-(3,5-dimethyl-1-piperazinyl)-6,8-difluoro-1,4-dihydro-4-oxo- 5-Amino-1-cyclopropyl-7-(cis-3,5-dimethyl-1-piperazinyl)-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid 5-Amino-1-cyclopropyl-7-(cis-3,5-dimethyl-1-piperazinyl)-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid 5-aMino-1-cyclopropyl-7-[(3R,5S)-3,5-diMethylpiperazin-1-yl]-6,8-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid |
| CAS | 111542-93-9 |
| 化学式 | C19H22F2N4O3 |
| 分子量 | 392.4 |
| InChI | InChI=1/C19H22F2N4O3/c1-8-5-24(6-9(2)23-8)17-13(20)15(22)12-16(14(17)21)25(10-3-4-10)7-11(18(12)26)19(27)28/h7-10,23H,3-6,22H2,1-2H3,(H,27,28) |
| 密度 | 1.436±0.06 g/cm3(Predicted) |
| 熔点 | 260-265 °C |
| 沸点 | 640.4±55.0 °C(Predicted) |
| 溶解度 | 氯仿 (微溶)，甲醇 (微溶，加热) |
| 酸度系数 | 6.42±0.50(Predicted) |
| 存储条件 | -20°C Freezer |
| 敏感性 | Sensitive to light |
| 外观 | 固体 |
| 颜色 | Pale Yellow to Yellow |
| 物化性质 | 黄色粉末。 |
| MDL号 | MFCD00869619 |
| 危险品标志 | Xi - 刺激性物品 |
| 风险术语 | 36/37/38 - 刺激眼睛、呼吸系统和皮肤。 |
| 安全术语 | S26 - 不慎与眼睛接触后，请立即用大量清水冲洗并征求医生意见。 S36 - 穿戴适当的防护服。 |
| WGK Germany | 2 |
| RTECS | VB1986500 |
| 上游原料 | 五氟苯甲酸 |
| 参考资料 展开查看 | 1. 田中华 朱深银 常淑芳 等. 司帕沙星对类风湿关节炎成纤维样滑膜细胞的声动力细胞毒性[J]. 第三军医大学学报 2018 40(19):44-48+57. 2. Fang, Jiajia, et al. "Detection of sparfloxacin based on water-soluble CuInS2 quantum dots." Results in Chemistry 2 (2020): 100027.https://doi.org/10.1016/j.rechem.2020.100027 3. Pan, Ziyu, et al. "High‐performance liquid chromatography study of gatifloxacin and sparfloxacin using erythrosine as post‐column resonance Rayleigh scattering reagent and mechanism study." Luminescence 33.2 (2018): 417-424.https://doi.org/10.1002/bio.3429 4. [IF=4.821] Ziyu Pan et al."Simultaneous determination of five fluoroquinolones by the selective high performance liquid chromatography associating with sensitive resonance light scattering and mechanism study."Microchem J. 2018 Jan;136:71 5. [IF=2.464] Ziyu Pan et al."High-performance liquid chromatography study of gatifloxacin and sparfloxacin using erythrosine as post-column resonance Rayleigh scattering reagent and mechanism study."Luminescence. 2018 Mar;33(2):417-424 |
