喹夫拉朋
MK-0591(MK-0591)
CAS: 136668-42-3
化学式: C34H35ClN2O3S
| 中文名 | MK-0591 |
| 英文名 | MK-0591 |
| 别名 | 喹夫拉朋 |
| 英文别名 | MK0591 MK 0591 MK-0591 MK 0591 Quiflapon QUIFLAPON MK 591(Quiflapon) MK-0591 (Quiflapon) 3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylMethoxy)-1H-indol-2-yl)-2,2-diMethylpropanoic acid 1H-Indole-2-propanoic acid, 1-[(4-chlorophenyl)Methyl]-3-[(1,1-diMethylethyl)thio]-α,α-diMethyl-5-(2-quinolinylMethoxy)- 1-[(4-Chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-alpha,alpha-dimethyl-5-(2-quinolinylmethoxy)-1H-indole-2-propanoic acid |
| CAS | 136668-42-3 |
| 化学式 | C34H35ClN2O3S |
| 分子量 | 587.17 |
| 密度 | 1.21±0.1 g/cm3(Predicted) |
| 沸点 | 751.3±60.0 °C(Predicted) |
| 酸度系数 | 4.70±0.10(Predicted) |
| 存储条件 | -20℃ |
| 体外研究 | Quiflapon is a potent inhibitor of leukotriene (LT) biosynthesis in intact human and elicited rat polymorphonuclear leukocytes (PMNLs) (IC 50 values 3.1 and 6.1 nM, respectively) and in human, squirrel monkey, and rat whole blood (IC 50 values 510, 69, and 9 nM, respectively). Quiflapon has no effect on rat 5-lipoxygenase. Quiflapon has a high affinity for 5-lipoxygenase activating protein (FLAP) as evidenced by an IC 50 value of 1.6 nM in a FLAP binding assay and inhibition of the photoaffinity labelling of FLAP by two different photoaffinity ligands. Inhibition of activation of 5-lipoxygenase was shown through inhibition of the translocation of the enzyme from the cytosol to the membrane in human PMNLs. |
| 体内研究 | Quiflapon is a potent inhibitor of LT biosynthesis in vivo, first, following ex vivo challenge of blood obtained from treated rats and squirrel monkeys, second, in a rat pleurisy model, and, third, as monitored by inhibition of the urinary excretion of LTE4 in antigen-challenged allergic sheep. Inhibition of antigen-induced bronchoconstriction by Quiflapon is observed in inbred rats pretreated with methysergide, Ascaris-challenged squirrel monkeys, and Ascaris-challenged sheep (early and late phase response) [1]. Pups were treated with either vehicle or Quiflapon 10, 20, or 40 mg/kg subcutaneously daily for days 1-4, 5-9, or 10-14. On day 14, the lungs were inflated, fixed, and stained for histopathological and morphometric analyses. Hyperoxia groups treated with Quiflapon untreated hyperoxia groups showed definite evidence of aberrant alveolarization but no inflammation. |
喹夫拉朋 - 配置溶液浓度参考
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.703 ml | 8.515 ml | 17.031 ml |
| 5 mM | 0.341 ml | 1.703 ml | 3.406 ml |
| 10 mM | 0.17 ml | 0.852 ml | 1.703 ml |
| 5 mM | 0.034 ml | 0.17 ml | 0.341 ml |
最后更新：2024-01-02 23:10:35
供应商列表
现货供应
产品名: MK591 free acid 去供应商网站查看 询盘CAS: 136668-42-3
产地: 上海
规格: M882948
价格: 10mg-1439,5mg-1069
库存: 15天内发货
电话: 13816333479/17821173903
手机: 13816333479/17821173903
电子邮件: wangrui@macklin.cn
QQ: 2881510266
微信: 19863730987/17821173903
现货供应
产品名: MK591 free acid 去供应商网站查看 询盘CAS: 136668-42-3
产地: 上海
规格: M882948
价格: 10mg-1439,5mg-1069
库存: 15天内发货
电话: 13816333479/17821173903
手机: 13816333479/17821173903
电子邮件: wangrui@macklin.cn
QQ: 2881510266
微信: 19863730987/17821173903
您刚刚浏览过
喹夫拉朋 2-methyl-1,4-oxazepane(SALTDATA: FREE) Einecs 282-006-5 C812-I Palladium(II)(π-cinnamyl) Chloride Dimer rac Tryptophan EP Impurity G 3-(2-甲酰基苯氧基)丙酸 1(2H)-BOC-7-氨基-3,4-二氢喹啉 3-乙氧基-4-甲氧基苄腈 (9'Z)-5,6-Dihydro-5,6-dihydroxy-β,β-carotene
你知道吗？
微信搜索化工百科或扫描下方二维码，添加化工百科小程序，随时随地查信息！