人参皂荚RH1
人参皂甙 Rh1(Ginsenoside Rh1)
CAS: 63223-86-9
化学式: C36H62O9
| 中文名 | 人参皂甙 Rh1 |
| 英文名 | Ginsenoside Rh1 |
| 别名 | 人参皂荚RH1 人参皂甙 Rh1 人参皂苷-RH1 人参皂苷 S-RH1 (R型)人参皂苷RH1 (S型)人参皂苷RH1 人参皂苷RH1(标准品) 人参皂苷RH1, 来源于人参 |
| 英文别名 | Ginsenoside Rh1 GINSENOSIDE RH1 sanchinoside rh1 Sanchinoside Rh1 Ginsenoside Rh1 (Prosapogenin A2 6α-(β-D-Glucopyranosyloxy)-dammara-24-ene-3β,12β,20-triol (20S)-6α-(β-D-Glucopyranosyloxy)dammar-24-ene-3β,12β,20-triol 3β,12β,20-Trihydroxy-5α-dammar-24-en-6α-yl β-D-glucopyranoside (20S)-6α-(β-D-Glucopyranosyloxy)-3β,12β,20-trihydroxydammara-24-ene (3beta,6alpha,12beta)-3,12,20-Trihydroxydammar-24-en-6-yl beta-D-glucopyranoside (3beta,6alpha,12beta)-3,12,20-trihydroxydammar-24-en-6-yl?beta-d-glucopyranoside (3beta,6alpha,9xi,12beta,13xi)-3,12,20-trihydroxydammar-24-en-6-yl beta-D-glucopyranoside |
| CAS | 63223-86-9 |
| 化学式 | C36H62O9 |
| 分子量 | 638.88 |
| InChI | InChI=1/C36H62O9/c1-19(2)10-9-13-36(8,43)20-11-15-34(6)26(20)21(38)16-24-33(5)14-12-25(39)32(3,4)30(33)22(17-35(24,34)7)44-31-29(42)28(41)27(40)23(18-37)45-31/h10,20-31,37-43H,9,11-18H2,1-8H3/t20-,21+,22-,23+,24+,25-,26-,27+,28-,29+,30-,31+,33+,34+,35+,36-/m0/s1 |
| 密度 | 1.23 |
| 沸点 | 755.1±60.0 °C(Predicted) |
| 比旋光度 | (c, 0.88 in MeOH)+20 |
| 闪点 | 410.457°C |
| 蒸汽压 | 0mmHg at 25°C |
| 溶解度 | 易溶于水、甲醇、乙醇，不溶于石油醚、乙醚、苯。 |
| 折射率 | 1.581 |
| 酸度系数 | 12.91±0.70(Predicted) |
| 存储条件 | 2-8°C |
| 外观 | 白色结晶性粉末 |
| 物化性质 | 白色粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于人参。 |
| MDL号 | MFCD09951797 |
| 体外研究 | The effect of Ginsenoside Rh1 is examined on adipogenesis in 3T3-L1 cells. Ginsenoside Rh1 potently inhibits the adipogenesis, as assessed by Oil-red O staining and lipid contents in 3T3-L1 adipocytes. Ginsenoside Rh1, at concentrations of 50 μM and 100 μM, inhibit the adipogenesis by 50% and 63%, respectively.The expression levels of adipocytespecific genes such as PPAR-γ, C/EBP-α, FAS, aFABP and some genes are examined during early phase of differentiation such as Pref-1, C/EBP-δ and Glucocorticoid receptor (GR). After the treatment with Ginsenoside Rh1 in 3T3-L1 cells, mRNA is extracted on 18 h and 24 h for Pref-1, C/EBP-δ and GR and day 8 for PPAR-γ, C/EBP-α, FAS, aFABP. Then, the expression profiles of adipocyte-specific genes are investigated by RT-PCR. PPAR-γ, C/EBP-α, FAS, and aFABP expressions are significantly increased in DMI-stimulated differentiated adipocyte compared to those of non-stimulated adipocyte cells. However, treatment with DMI in the presence of Ginsenoside Rh1 significantly suppresses the expression levels of PPAR-γ, C/EBP-α, FAS, and aFABP in a dose- dependent manner, whereas the expression levels of Pref-1, C/EBP-δ and GR are not affected. |
| 体内研究 | When high-fat diet (HFD) fed mice for 8 weeks, body and epididymal fat weight gains are significantly increased compared to those of low-fat diet (LFD)-fed mice. However, when Ginsenoside Rh1 is treated in HFD-fed mice, body and epididymal fat weight gains are significantly decrease compared with those of the HFD-fed mice. TG, glucose, insulin, total cholesterol, and HDL levels in the blood are significantly increased in HFD-fed mice group compared to LFD-fed mice group. Treatment with Ginsenoside Rh1 in HFD-fed mice significantly lowers TG level alone. |
| 参考资料 展开查看 | 1. 钟雅婷 茅仁刚 宋纯清 等. RP-HPLC同时测定西洋参总皂苷转化产物中人参皂苷Rg1 Rh1 Rd Rg3和C-K的含量[J]. 江西中医药 2012 43(8):61-64. 2. 董坤园, 于澎, 熊金路,等. 基于高效液相色谱图谱结合化学计量学的红参指纹图谱研究[J]. 食品安全质量检测学报, 2019, 010(021):7316-7321. 3. 张博, 孙秀丽, 郭云龙,等. 液质联用技术分析不同产地不同年限人参的化学成分[J]. 中国实验方剂学杂志, 2020年26卷8期, 206-212页, ISTIC PKU CSCD CA, 2020. 4. 张琰, 李方彤, 韩铭鑫,等. 通过RRLC-Q-TOF MS和UPLC-QQQ MS分析原人参三醇型皂苷在人肠道菌群中的代谢产物[J]. 质谱学报, 2020(1):66-75. 5. 夏晚霞, 张尚微, 葛亚中,等. 乳酸菌发酵转化人参皂苷[J]. 现代食品科技, 2018, 34(09):136-142. 6. 越皓,周东月,张美玉,张琰,戴雨霖,郑飞,朱英豪.红参中原人参三醇型皂苷组在肠道菌群中体外转化及对肠道菌群的作用[J].应用化学,2021,38(03):323-330. 7. Zhang, Hong-Mei, et al. "Holistic quality evaluation of commercial white and red ginseng using a UPLC-QTOF-MS/MS-based metabolomics approach." Journal of pharmaceutical and biomedical analysis 62 (2012): 258-273.https://doi.org/10.1016/j.jpba.2012.01.010 8. Qin, Z., Jia, M., Yang, J. et al. Multiple circulating alkaloids and saponins from intravenous Kang-Ai injection inhibit human cytochrome P450 and UDP-glucuronosyltransferase isozymes: potential drug–drug interactions. Chin Med 15, 69 (2020). https://doi.o 9. Hong Zhang, Jia-Ming Jiang, Dan Zheng, Ming Yuan, Zhi-Ying Wang, Hong-Mei Zhang, Chang-Wu Zheng, Lian-Bo Xiao, Hong-Xi Xu,A multidimensional analytical approach based on time-decoupled online comprehensive two-dimensional liquid chromatography coupled wit 10. Hong Zhang, Jia-Ming Jiang, Dan Zheng, Ming Yuan, Zhi-Ying Wang, Hong-Mei Zhang, Chang-Wu Zheng, Lian-Bo Xiao, Hong-Xi Xu,A multidimensional analytical approach based on time-decoupled online comprehensive two-dimensional liquid chromatography coupled wit 11. Hong Zhang, Jia-Ming Jiang, Dan Zheng, Ming Yuan, Zhi-Ying Wang, Hong-Mei Zhang, Chang-Wu Zheng, Lian-Bo Xiao, Hong-Xi Xu,A multidimensional analytical approach based on time-decoupled online comprehensive two-dimensional liquid chromatography coupled wit 12. Yongshen Ren, Jiao Ai, Xinqiao Liu, Shuai Liang, Yao Zheng, Xin Deng, Yan Li, Jing Wang, Xukun Deng, Lin-Lin Chen,Anticoagulant active ingredients identification of total saponin extraction of different Panax medicinal plants based on grey relational anal 13. [IF=6.06] Yang Xiu et al."Simultaneous determination and difference evaluation of 14 ginsenosides in Panax ginseng roots cultivated in different areas and ages by high-performance liquid chromatography coupled with triple quadrupole mass spectrometer in the multipl 14. [IF=5.34] Shan-Shan Zhou et al."Stronger anti-obesity effect of white ginseng over red ginseng and the potential mechanisms involving chemically structural/compositional specificity to gut microbiota."Phytomedicine. 2020 Aug;74:152761 15. [IF=4.36] Bin Ma et al."Sulfur fumigation reducing systemic exposure of ginsenosides and weakening immunomodulatory activity of ginseng."J Ethnopharmacol. 2017 Jan;195:222 16. [IF=3.935] Hong-Mei Zhang et al."Holistic quality evaluation of commercial white and red ginseng using a UPLC-QTOF-MS/MS-based metabolomics approach."J Pharmaceut Biomed. 2012 Mar;62:258 17. [IF=3.935] Hong Zhang et al."A multidimensional analytical approach based on time-decoupled online comprehensive two-dimensional liquid chromatography coupled with ion mobility quadrupole time-of-flight mass spectrometry for the analysis of ginsenosides from white a 18. [IF=3.935] Shan-Shan Zhou et al."Synchronous characterization of carbohydrates and ginsenosides yields deeper insights into the processing chemistry of ginseng."J Pharmaceut Biomed. 2017 Oct;145:59 19. [IF=6.558] Qingqing Song et al."Binary code, a flexible tool for diagnostic metabolite sequencing of medicinal plants."Anal Chim Acta. 2019 Dec;1088:89 20. [IF=4.411] Jianbo Chen et al."Neuroprotective Effects of Red Ginseng Saponins in Scopolamine-Treated Rats and Activity Screening Based on Pharmacokinetics."Molecules. 2019 Jan;24(11):2136 21. [IF=4.36] Yongshen Ren et al."Anticoagulant active ingredients identification of total saponin extraction of different Panax medicinal plants based on grey relational analysis combined with UPLC-MS and molecular docking."J Ethnopharmacol. 2020 Oct;260:112955 22. 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产品名: 人参皂苷Rh1 标准品 去供应商网站查看 询盘CAS: 63223-86-9
产地: 北京
包装: 瓶
规格: SG8390-20mg,20mg,IG0270-D-1ml,10mM*1ml(inDMSO),IG0270-10mg,10mg,IG0270-20mg,20mg
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库存: 现询
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手机: 17801761073(微信同号)
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产品描述: 产品覆盖：小分子化合物、分析对照品、染色试剂、生化试剂盒、细胞生物学、分子生物学、抗体、蛋白、多肽、ELISA试剂盒、微生物培养、化学合成、仪器耗材、CRO技术 更多
提供多种规格现货供应
产品名: Ginsenoside Rh1 去供应商网站查看 询盘CAS: 63223-86-9
产地: 美国
包装: 10 mM * 1 mL;5 mg;10 mg
规格: HY-N0604
库存: 现货，货期：1-2天
电话: 021-38924433; 021-58955995
手机: 18019480960
电子邮件: sales@medchemexpress.cn
产品描述: 产品覆盖：8万多种抑制剂，11000+靶点蛋白，数百款试剂盒，200+生物活性化合物库，天然产物，抗体等. 纯度: ≥98.0%
现货供应
产品名: 人参皂苷Rh1 标准品 去供应商网站查看 询盘CAS: 63223-86-9
产地: 北京
包装: 瓶
规格: SG8390-20mg,20mg,IG0270-D-1ml,10mM*1ml(inDMSO),IG0270-10mg,10mg,IG0270-20mg,20mg
价格: 电话、微信、QQ、邮件
库存: 现询
电话: 010-50973130
手机: 17801761073(微信同号)
电子邮件: 3193328036@qq.com
QQ: 3193328036
微信: 17801761073
产品描述: 产品覆盖：小分子化合物、分析对照品、染色试剂、生化试剂盒、细胞生物学、分子生物学、抗体、蛋白、多肽、ELISA试剂盒、微生物培养、化学合成、仪器耗材、CRO技术 更多
提供多种规格现货供应
产品名: Ginsenoside Rh1 去供应商网站查看 询盘CAS: 63223-86-9
产地: 美国
包装: 10 mM * 1 mL;5 mg;10 mg
规格: HY-N0604
库存: 现货，货期：1-2天
电话: 021-38924433; 021-58955995
手机: 18019480960
电子邮件: sales@medchemexpress.cn
产品描述: 产品覆盖：8万多种抑制剂，11000+靶点蛋白，数百款试剂盒，200+生物活性化合物库，天然产物，抗体等. 纯度: ≥98.0%
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