二氢欧山芹当归酸酯

中文名	二氢欧山芹醇当归酸酯
英文名	Columbianadin
别名	二氢山芹醇当归酯氢欧山芹醇当归酸酯二氢欧山芹当归酸酯二氢欧山芹醇当归酸脂二氢欧山芹醇当归酸酯二氢欧山芹醇当归酸酯(标准品) 二氢欧山芹醇当归酸酯, 来源于独活二氢欧山芹醇当归酸酯(分析标准品) COLUMBIANADIN 二氢欧山芹醇当归酸酯
英文别名	ZosiMin Zosimin ColuMbianin Columbianadin Columbianetin angelate Columbianadin 5058-13-9 Columbianadin Columbianadin 1-methyl-1-[(8S)-2-oxo-8,9-dihydro-2H-furo[2,3-h]chromen-8-yl]ethyl (2Z)-2-methylbut-2-enoate (S)-8-[1-[(Z)-2-Methyl-2-butenoyloxy]-1-methylethyl]-8,9-dihydro-2H-furo[2,3-h]-1-benzopyran-2-one 2-Butenoic acid, 2-methyl-, 1-(8,9-dihydro-2-oxo-2H-furo(2,3-h)-1-benzopyran-8-yl)-1-methylethyl ester, (S-(Z))-
CAS	5058-13-9
化学式	C19H20O5
分子量	328.36
InChI	InChI=1/C19H20O5/c1-5-11(2)18(21)24-19(3,4)15-10-13-14(22-15)8-6-12-7-9-16(20)23-17(12)13/h5-9,15H,10H2,1-4H3/b11-5-/t15-/m0/s1
密度	1.232±0.06 g/cm3(Predicted)
熔点	117.0 to 121.0 °C
沸点	482.3±45.0 °C(Predicted)
比旋光度	(CHCl3)+272
闪点	212.7°C
蒸汽压	1.84E-09mmHg at 25°C
溶解度	溶于氯仿、乙醇、甲醇、乙/醚醋酸乙脂、丙酮，也能溶于沸水，不溶于冷水。
折射率	1.569
存储条件	2-8℃
外观	粉末或结晶
颜色	White to Almost white
物化性质	白色针状结晶，易溶于甲醇、乙酸乙酯、三氯甲烷、丙酮、乙醚，来源于独活，蛇床子。
MDL号	MFCD07781426
体外研究	Columbianadin (CBN) effectively suppresses the growth of colon cancer cells. Low concentration (up to 25 μM) of Columbianadin induces apoptosis, and high concentration (50 μM) of Columbianadin induces necroptosis. The induction of apoptosis by Columbianadin is correlated with the modulation of caspase-9, caspase-3, Bax, Bcl-2, Bim and Bid, and the induction of necroptosis is related with RIP-3, and caspase-8. In addition, Columbianadin induces the accumulation of ROS and imbalance in the intracellular antioxidant enzymes such as SOD-1, SOD-2, catalase and GPx-1. Columbianadin shows the most effective growth inhibitory activity against human colorectal cancer cells. Accordingly, further study is performed using HCT116 cells to give the detailed growth-inhibitory mechanism of action mediated by Columbianadin. The cells treated with various concentrations of Columbianadin (0-100 μM) exhibit a dose- and time-dependent growth inhibition with an IC 50 value of 47.2 and 32.4 μM after 48 and 72 h incubation, respectively. Treatment of various concentrations (12.5, 25, and 50 μM) of Columbianadin for 48 h in HCT116 cells decreases the number of cells and increases the floating cells. Apparent morphological changes with round-shape and dying cells are also observed at 25 and 50 μM Columbianadin -treated cells.
体内研究	The analysis method is successfully applied to a tissue distribution study of Columbianadin (CBN) and Columbianetin (CBT) after intravenous administration of Columbianadin to rats. The results of this study indicated that Columbianadin can be detected in all of the selected tissues after i.v. administration. Columbianadin is distributed to rat tissues rapidly and can be metabolized to CBT in most detected tissues. Of the detected tissues, heart had the highest uptake of Columbianadin, which suggests that heart might be one of the main target tissues of Columbianadin .
安全术语	24/25 - 避免与皮肤和眼睛接触。
海关编号	29329990
参考资料展开查看	1. 冯雪,高玉乔,范琼瑛,苏军华,赵宝华.采用LC-ESI/MS方法同时测定荆防败毒口服液中4个有效成分含量[J].药物分析杂志,2017,37(08):1489-1496. 2. Yang, Yan-Fang, Lei Zhang, and Xiu-Wei Yang. "Distribution assessments of coumarins from Angelicae Pubescentis Radix in rat cerebrospinal fluid and brain by Liquid Chromatography Tandem Mass Spectrometry analysis." Molecules 23.1 (2018): 225.https://doi.or 3. [IF=3.361] Shan Huang et al."Cytochrome c-multiwalled carbon nanotube and cobalt metal organic framework/gold nanoparticle immobilized electrochemical biosensor for nitrite detection."Rsc Adv. 2020 Dec;11(1):501-509

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