Nitrilotriacetic acid
Nitrilotriacetic acid
CAS: 139-13-9
Molecular Formula: C6H9NO6
Nitrilotriacetic acid - Names and Identifiers
| Name | Nitrilotriacetic acid |
| Synonyms | NTA Noname chel300 chel 300 Trilone A ai3-52483 titriplexi triglycine complexoni komplexoni nci-c02766 Complexon I titriplex i versene nta acid hampshirentaacid hampshire nta acid aminotriacetic acid triglycollamic acid nitrilotri-aceticaci Nitrilortiaceticacid Nitrilotriacetic acid Nitrilo triacetic acid tri(carboxymethyl)amine kyselinanitrilotrioctova Glycine,N,N-bis(carboxyme N,N-bis(carboxymethyl)glycine nitrilo-2,2',2''-triaceticacid kyselinanitrilotrioctova(czech) nitrilo-2,2',2''-triacetic acid nitrilotris(methylenecarboxylicacid) Trimethylamine-α,α',α''-tricarboxylic acid alpha,alpha',alpha''-trimethylaminetricarboxylic acid |
| CAS | 139-13-9 |
| EINECS | 205-355-7 |
| InChI | InChI=1/C6H9NO6/c8-4(9)1-7(2-5(10)11)3-6(12)13/h1-3H2,(H,8,9)(H,10,11)(H,12,13) |
Nitrilotriacetic acid - Physico-chemical Properties
| Molecular Formula | C6H9NO6 |
| Molar Mass | 191.14 |
| Density | 1.5784 (rough estimate) |
| Melting Point | 245°C (dec.)(lit.) |
| Boling Point | 326.86°C (rough estimate) |
| Flash Point | 100°C |
| Water Solubility | Insoluble. |
| Solubility | 0.1 M NaOH: 0.1M at20°C, clear, colorless |
| Vapor Presure | 0-0Pa at 20-25℃ |
| Appearance | White crystal |
| Color | White |
| Maximum wavelength(λmax) | ['λ: 260 nm Amax: 1.5', , 'λ: 280 nm Amax: 0.05'] |
| Merck | 14,6579 |
| BRN | 1710776 |
| pKa | 3.03, 3.07, 10.70(at 20℃) |
| Storage Condition | 2-8°C |
| Sensitive | Easily absorbing moisture |
| Refractive Index | 1.4860 (estimate) |
| MDL | MFCD00004287 |
| Physical and Chemical Properties | Character white crystalline powder. soluble in aqueous ammonia and alkali solution, slightly soluble in hot water, insoluble in water and most organic solvents. Other properties decompose when heated to ≥ 246 ℃ to produce toxic smoke containing carbon monoxide, carbon dioxide and nitrogen oxides soluble in ammonia and alkaline solution, slightly soluble in hot water, insoluble in organic solvents. It cannot coexist with strong oxidants, aluminum, copper, copper alloys and nickel. |
| Use | It is a good fixing agent in the dye industry, plays a role in the production of styrene, plays a role in the production of polyurethane foam, such as Catalyst and complexing agent |
Nitrilotriacetic acid - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R36 - Irritating to the eyes R40 - Limited evidence of a carcinogenic effect R36/37/38 - Irritating to eyes, respiratory system and skin. R45 - May cause cancer R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S53 - Avoid exposure - obtain special instructions before use. |
| UN IDs | 2811 |
| WGK Germany | 2 |
| RTECS | AJ0175000 |
| FLUKA BRAND F CODES | 21 |
| TSCA | Yes |
| HS Code | 29224995 |
| Hazard Class | 8 |
| Packing Group | II |
| Toxicity | LD50 orally in Rabbit: 1100 mg/kg |
Nitrilotriacetic acid - Upstream Downstream Industry
| Raw Materials | Sulfuric acid Ammonium chloride Chloroacetic acid |
Nitrilotriacetic acid - Nature
Open Data Verified Data
White rhomboid crystals. Soluble in ammonia, sodium hydroxide solution. Slightly soluble in water, 1L of water can dissolve 22.5g of amino triacetic acid at 2.3 ℃, and the pH value of saturated aqueous solution is. Insoluble in most organic solutions. Flammable, in case of fire, high heat, oxidant has caused the risk of combustion.
Last Update：2025-06-10 22:55:16
Nitrilotriacetic acid - Preparation Method
Open Data Verified Data
sodium chloroacetate is formed by the reaction of chloroacetic acid with sodium hydroxide, and then reacts with ammonium chloride to form sodium aminotriacetate, which is then acidified to obtain a finished product.
Last Update：2025-06-10 22:55:16
Nitrilotriacetic acid - Introduction
Insoluble in water, soluble in ammonia or hydroxide solution, soluble in most organic solvents. Solubility in water: 1 · 28g/L (22 · 5°C).
Last Update：2022-10-16 17:13:47
Nitrilotriacetic acid - Use
Open Data Verified Data
nitrilotriacetic acid is an organic polycarboxylic acid chelating agent, because of its small molecule, it can chelate more metals and has strong biodegradability. Adding a certain amount of reducing agent and pH Adjusting Agent to hypoaminotriacetic acid, the effect of removing Fe2 03 and red iron oxide is excellent.
Last Update：2025-06-10 22:55:16
Nitrilotriacetic acid - Safety
Open Data Verified Data
rat oral LD50:1.47g/kg. Inhalation, ingestion of harmful to the body, can cause irritation. No occupational poisoning was reported. Store in a cool, ventilated warehouse. Keep away from fire and heat source. Protection from direct sunlight. Keep the container sealed. Should be stored separately from the oxidant, acid, alkali. Aminotriacetic acid is non-toxic. Pay attention to moisture and fire prevention during storage and transportation.
Last Update：2022-01-01 09:29:57
Nitrilotriacetic acid - Reference Information
| LogP | -3.81 at 25℃ |
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| (IARC) carcinogen classification | 2B (Vol. 48, 73) 1999 |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| use | is a very good fixing agent in the dye industry. it acts as a stabilizer in styrene production and acts as a catalyst and complexing agent in polyurethane foam production it is used as a complexing reagent and also used in cyanide-free electroplating this product is used as complexing agent in the electroplating industry to replace sodium cyanide for cyanide-free electroplating. It is also used as a metal ion chelating agent and is widely used in textile, paper and other industries. The main uses are as follows. 1. Complexing agent It is the complexing agent of everyone, which can form metal complexes with various metals, analyze and determine, and separate rare metals. It can also be used to extract individual metals from rare metals. 2. Catalyst In the production of polyurethane foam, it can be used as a foaming catalyst, which can foam immediately and gel quickly. 3. Stabilizer In the production of polystyrene, it can be used as a stabilizer. 4. Detergent In the steam generator system of the nuclear reactor, it can be used as an aqueous solution to inject steam-water circulation to remove scale and corrosive substances between the walls, and does not affect the efficiency during the addition process. 5. Electroplating agent in non-toxic electroplating, it can speed up the deposition speed. 6. Color photographic developer is one of the important components in color photographic development, which can be used to prevent precipitation during development. As a substitute for tripolyphosphate, Azagawa triacetic acid has also received attention in solving the problem of eutrophication of water bodies in synthetic detergents. Complexing agent, commonly used in the determination of calcium, magnesium, iron and other cations, metal masking agent. |
| Production method | The reaction of chloroacetic acid and sodium hydroxide produces sodium chloroacetate, and then ammonium chloride reacts to produce sodium aminotriacetate, which is then acidified to obtain the finished product. The chloroacetic acid method is backward in technology and high in cost, and has been eliminated abroad. A large number of by-product HCN manufacturers in the United States and Japan adopt the Stolig method. Pure liquid HCN and formaldehyde react with ammonia or amine salt under acidic conditions to generate nitrotricarbamide, and then hydrolyze to obtain NTA. The method has high investment and operating costs and poor security. Another method is the carboxymethylation method successfully developed abroad in the 1970s. The method adopts NaCN, which is convenient for storage and transportation. The reaction is carried out under alkaline conditions, does not produce volatile HCN, and has good production safety. The production cost of this method is 45-50% lower than that of chloroacetic acid method. Raw material consumption (kg/t) chloroacetic acid 1770 ammonium chloride 440 885 kg monochloroacetic acid is put into an acid-resistant kettle, heated to 64 ℃ under stirring, and 1 220kg 30% of liquid alkali is added dropwise after full melting for neutralization reaction. React at 80~90 ℃ for 5~6 h. An aqueous solution of sodium monochloroacetic acid is obtained. The neutralization liquid is fed into a thin film evaporator and concentrated under vacuum. When it is close to saturation, it is driven into a condensation kettle, heated to 60 ℃, and adjusted to 7~8 with sodium carbonate saturated solution. Continue to raise the temperature to 80 ℃, and add 400 kg of ammonium chloride saturated solution under stirring. After adding, stir for 5 min and mix evenly. Then adjust the pH value to 9~10 with liquid alkali. Stop the reaction. Let stand for 4 h. Filtering. Collect the filtrate. The filtrate is fed into the acidification kettle, and hydrochloric acid is added to acidify. When the pH value reaches 0.5~1.2, the acid is stopped. Cool and let stand, crystallize. The upper liquid is sucked out, washed and crystallized several times with water, and dried to obtain the finished product. |
| category | toxic substances |
| toxicity classification | poisoning |
| acute toxicity | oral-rat LD50: 1100 mg/kg; Oral-mouse LD50: 3160 mg/kg |
| flammability hazard characteristics | flammability; high temperature produces toxic nitrogen oxide smoke |
| storage and transportation characteristics | warehouse ventilation and low temperature drying |
| fire extinguishing agent | dry powder, foam, sand, carbon dioxide, mist water |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-10 22:29:15
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Raw Materials for Nitrilotriacetic acid