N-Methyl-N,N-bis(2-pyridylethyl)amine
N-Methyl-N,N-bis(2-pyridylethyl)amine
CAS: 5452-87-9
Molecular Formula: C15H19N3
N-Methyl-N,N-bis(2-pyridylethyl)amine - Names and Identifiers
N-Methyl-N,N-bis(2-pyridylethyl)amine - Physico-chemical Properties
| Molecular Formula | C15H19N3 |
| Molar Mass | 241.33 |
| Density | 1.067±0.06 g/cm3(Predicted) |
| Boling Point | 126-127 °C(Press: 0.08 Torr) |
| Solubility | Chloroform (Slightly), Dichloromethane (Slightly), Ethanol (Slightly), Ethyl Ace |
| Appearance | Form Solid, color Pale Yellow to Light Yellow Oil to Sticky |
| Color | Pale Yellow to Light Yellow Oil to Sticky |
| pKa | 8.17±0.50(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Physical and Chemical Properties | The bioactive Betahistine EP Impurity C (NSC19005) is a Betahistine impurity. Betahistine is an orally potent histamine H1 receptor agonist and H3 receptor antagonist used in the study of rheumatoid arthritis (RA). |
| In vitro study | Betahistine (0-10 μM) inhibits [ 125 I]iodoproxyfan binding to membranes of CHO (rH 3(445) R) and CHO (hH 3(445) R) cells with IC 50 values of 1.9 μM and 3.3 μM, respectively. Lead to K i values of 1.4 μM and 2.5 μM, respectively. |
N-Methyl-N,N-bis(2-pyridylethyl)amine - Upstream Downstream Industry
| Raw Materials | 2-Pyridineethanamine, N-[2-(2-pyridinyl)ethyl]- Betahistine dihydrochloride Betahistine Methylamine Formaldehyde 2-Vinylpyridine |
N-Methyl-N,N-bis(2-pyridylethyl)amine - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 4.144 ml | 20.719 ml | 41.437 ml |
| 5 mM | 0.829 ml | 4.144 ml | 8.287 ml |
| 10 mM | 0.414 ml | 2.072 ml | 4.144 ml |
| 5 mM | 0.083 ml | 0.414 ml | 0.829 ml |
Last Update：2024-01-02 23:10:35
N-Methyl-N,N-bis(2-pyridylethyl)amine - Nature
| Solubility | Chloroform (Slightly), Dichloromethane (Slightly), Ethanol (Slightly), Ethyl Ace |
Last Update：2024-04-10 22:29:15
N-Methyl-N,N-bis(2-pyridylethyl)amine - Introduction
N-Methyl-N,N-bis(2-pyridylethyl)amine, also known as DMPEA, is an organic compound. The following is an introduction to its nature, use, formulation and safety information:
Nature:
N-Methyl-N,N-bis(2-pyridylethyl)amine is a colorless to pale yellow liquid with a pungent odor. It is flammable and insoluble in water, but can be dissolved in many organic solvents. It is a weakly alkaline compound.
Use:
N-Methyl-N,N-bis(2-pyridylethyl)amine is often used as a base catalyst in organic synthesis reactions, especially in hydrogenation reactions and amide synthesis. It can also act as an accelerator and solvent for photochemical reactions.
Preparation Method:
N-Methyl-N,N-bis(2-pyridylethyl)amine can be prepared by reacting dioxanamide with methylacetamide in the presence of a base.
Safety Information:
N-Methyl-N,N-bis(2-pyridylethyl)amine is irritating and avoid contact with skin and eyes. When in use, need to wear protective glasses and gloves. Avoid inhaling its vapors and operate in a well-ventilated place. When stored and transported, it should be placed in a sealed container, away from fire and oxidizing agents. In case of misuse or skin contact, seek medical advice or rinse immediately.
Nature:
N-Methyl-N,N-bis(2-pyridylethyl)amine is a colorless to pale yellow liquid with a pungent odor. It is flammable and insoluble in water, but can be dissolved in many organic solvents. It is a weakly alkaline compound.
Use:
N-Methyl-N,N-bis(2-pyridylethyl)amine is often used as a base catalyst in organic synthesis reactions, especially in hydrogenation reactions and amide synthesis. It can also act as an accelerator and solvent for photochemical reactions.
Preparation Method:
N-Methyl-N,N-bis(2-pyridylethyl)amine can be prepared by reacting dioxanamide with methylacetamide in the presence of a base.
Safety Information:
N-Methyl-N,N-bis(2-pyridylethyl)amine is irritating and avoid contact with skin and eyes. When in use, need to wear protective glasses and gloves. Avoid inhaling its vapors and operate in a well-ventilated place. When stored and transported, it should be placed in a sealed container, away from fire and oxidizing agents. In case of misuse or skin contact, seek medical advice or rinse immediately.
Last Update：2024-04-09 01:59:56
N-Methyl-N,N-bis(2-pyridylethyl)amine - In vitro study
Betahistine (0-10 μM) inhibits [ 125 I ]iodoproxyfan binding to membranes of CHO (rH 3(445) R) and CHO (hH 3(445) R) cells with IC 50 values of 1.9 μM and 3.3 μM, respectively. Lead to K I values of 1.4 μM and 2.5 μM, respectively.
Last Update：2024-04-09 20:52:54
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View History
Raw Materials for N-Methyl-N,N-bis(2-pyridylethyl)amine
2-Pyridineethanamine, N-[2-(2-pyridinyl)ethyl]-
Betahistine dihydrochloride
Betahistine
Methylamine
Formaldehyde
2-Vinylpyridine
Betahistine dihydrochloride
Betahistine
Methylamine
Formaldehyde
2-Vinylpyridine