D-2-Aminobutanedioic acid
D(-)-Aspartic acid
CAS: 1783-96-6
Molecular Formula: C4H7NO4
D-2-Aminobutanedioic acid - Names and Identifiers
| Name | D(-)-Aspartic acid |
| Synonyms | H-D-Asp d-aspartic H-D-Asp-OH d-asparticaci D-Aspartic acid l-Asparagic acid D(-)-Aspartic acid D-Aminosuccinic acid (R)-(-)-ASPARTIC ACID (R)-AMINOSUCCINIC ACID D-2-Aminobutanedioic acid 1-Amino-1,2-carboxyethane (R)-(-)-AMINOSUCCINIC ACID |
| CAS | 1783-96-6 |
| EINECS | 217-234-6 |
| InChI | InChI=1/C8H12N2O8/c9-8(7(17)18,2-5(13)14)10-3(6(15)16)1-4(11)12/h3,10H,1-2,9H2,(H,11,12)(H,13,14)(H,15,16)(H,17,18)/t3?,8-/m1/s1 |
| InChIKey | CKLJMWTZIZZHCS-UWTATZPHSA-N |
D-2-Aminobutanedioic acid - Physico-chemical Properties
| Molecular Formula | C4H7NO4 |
| Molar Mass | 133.1 |
| Density | 1.66 |
| Melting Point | >300°C(lit.) |
| Boling Point | 245.59°C (rough estimate) |
| Specific Rotation(α) | -25.8 º (c=5, 5N HCl) |
| Water Solubility | SOLUBLE |
| Solubility | Aqueous Acid (Sparingly) |
| Appearance | White or white-like crystals |
| Color | White to off-white |
| Merck | 14,840 |
| BRN | 1723529 |
| pKa | pK1: 1.89(0);pK2: 3.65;pK3: 9.60 (25°C) |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| Refractive Index | -25 ° (C=8, 50% HCl) |
| MDL | MFCD00063081 |
| Physical and Chemical Properties | Appearance White or almost white crystalline powder specific rotation [a]20D -24 ° ~ -26 ° |
| Use | Used in the synthesis of pharmaceuticals, pharmaceutical intermediates or APIs |
D-2-Aminobutanedioic acid - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S24/25 - Avoid contact with skin and eyes. S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| RTECS | CI9097500 |
| HS Code | 29224995 |
D-2-Aminobutanedioic acid - Reference
| Reference Show more | 1. [IF=7.79] Ye Lu et al."Enhancing hydrogel-based long-lasting chemiluminescence by a platinum-metal organic framework and its application in array detection of pesticides and D-amino acids."Nanoscale. 2020 Feb;12(8):4959-4967 2. [IF=5.537] Yurong Ma et al."Pre-cut NaCl solution treatment effectively inhibited the browning of fresh-cut potato by influencing polyphenol oxidase activity and several free amino acids contents."Postharvest Biol Tec. 2021 Aug;178:111543 3. [IF=4.556] Dandan Zhao et al."Physico-chemical properties and free amino acids profiles of six wolfberry cultivars in Zhongning."J Food Compos Anal. 2020 May;88:103460 4. [IF=4.379] Feng Lin et al."Chemical profile changes during pile fermentation of Qingzhuan tea affect inhibition of α-amylase and lipase."Sci Rep-Uk. 2020 Feb;10(1):1-10 5. [IF=4.35] Xiaomei Dai et al."1-Methylcyclopropene Preserves the Quality of Chive (Allium schoenoprasum L.) by Enhancing Its Antioxidant Capacities and Organosulfur Profile during Storage."Foods. 2021 Aug;10(8):1792 6. [IF=2.752] Yuting Zhang et al."Metabolomic Analysis and Identification of Sperm Freezability-Related Metabolites in Boar Seminal Plasma."Animals-Basel. 2021 Jul;11(7):1939 7. [IF=4.242] Hang Yang et al."Dietary leucine requirement of juvenile largemouth bass (Micropterus salmoides) based on growth, nutrient utilization and growth-related gene analyses."Aquaculture. 2022 Jun;555:738207 |
D-2-Aminobutanedioic acid - Standard
Authoritative Data Verified Data
This product is L-2-amino succinic acid. The content of C4H7N04 shall not be less than 98.5% calculated as dried product.
Last Update：2024-01-02 23:10:35
D-2-Aminobutanedioic acid - Trait
Authoritative Data Verified Data
- This product is white or off-white crystalline or crystalline powder; Odorless.
- This product is dissolved in hot water, slightly soluble in water, insoluble in ethanol, dissolved in dilute hydrochloric acid or sodium hydroxide solution.
specific rotation
take this product, precision weighing, add 6mol/L hydrochloric acid solution to dissolve and quantitatively dilute to make a solution containing about 80mg per lml, and determine according to law (General 0621), the specific rotation was 24.0 ° to 26.0 °.
Last Update：2022-01-01 11:30:56
D-2-Aminobutanedioic acid - Introduction
Soluble in water, insoluble in alcohol and ether.
Last Update：2022-10-16 17:14:30
D-2-Aminobutanedioic acid - Differential diagnosis
Authoritative Data Verified Data
- 10mg of this product and 10mg of the reference sample of aspartic acid were placed in a 25ml measuring flask respectively, and 2ml of ammonia test solution was added to dissolve the solution. The solution was diluted with water to scale, and then shaken well to be used as a test solution and a reference solution. According to the chromatographic condition test under other amino acids, the position and color of the main spot of the test solution should be the same as that of the reference solution.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 913).
Last Update：2022-01-01 11:30:57
D-2-Aminobutanedioic acid - Exam
Authoritative Data Verified Data
acidity
take 0.10g of this product, add 20ml of water to dissolve, and then measure it according to law (General rule 0631). The pH value should be 2.0~4.0.
transmittance of solution
take 1.0g of this product, add lmol/L hydrochloric acid solution 10ml to dissolve, according to ultraviolet-visible spectrophotometry (General rule 0401), measure transmittance at 430mn wavelength, not less than 98.0%.
chloride
take 0.30g of this product and check it according to law (General rule 0801). Compared with the control solution made of 6.0ml of standard sodium chloride solution, it should not be more concentrated (0.02%).
sulfate
take l.Og of this product and check it according to law (General rule 0802). Compared with the control solution made of 0.02% of standard potassium sulfate solution, it should not be more concentrated ().
ammonium salt
take 0.10g of this product and check it according to law (General rule 0808). Compared with the control solution made of 0.02% of standard ammonium chloride solution, it shall not be deeper ().
other amino acids
take 0.10g of this product, put it in a 10ml measuring flask, add 2ml of concentrated ammonia solution to dissolve, dilute with water to the scale, shake well, and use it as a test solution. Take 1 ml for precision measurement, put it in a 200ml measuring flask, dilute it to the scale with water, shake it well, and use it as a control solution; Take 10 mg of aspartic acid reference product and 10 mg of glutamic acid reference product, put them in the same 25ml measuring flask, and add 2ml of Ammonia Test Solution to dissolve them, dilute to the scale with water and shake well as a system-suitable solution. According to the thin layer chromatography (General 0502) test, absorb the above three solutions each 5 u1, respectively, on the same silica gel G thin layer plate, with glacial acetic acid-water-n-butanol (1:1:3) for Development, spread at least 15cm, dry, spray with 0.2% ninhydrin in n-butanol -2mol/L acetic acid solution (95:5) mixture solution, and heat at 105°C for about 15 minutes until spots appear, immediate review. The control solution should show a clear spot, and the system applicable solution should show two clearly separated spots. If the test solution shows impurity spots, the color should not be deeper (0.5%) than the main spot of the control solution.
loss on drying
take this product, dry at 105°C for 3 hours, loss of weight shall not exceed 0.2% (General rule 0831).
ignition residue
This product l.Og, according to law inspection (General rule 0841), residual shall not exceed 0.1%.
Iron Salt
take l.Og of this product and check it according to law (General rule 0807). Compared with the control solution made of 0.001% of standard iron solution, it shall not be deeper ().
Heavy metals
The residue left under the item of taking the ignition residue shall not contain more than 10 parts per million of heavy metal when examined by law (General Principles 0821, Law II).
arsenic salt
take this product 2. G, add water 23ml dissolved, add hydrochloric acid 5ml, according to the law inspection (General Principles 0822 first law), should comply with the provisions (0.0001%).
pyrogen
This product is dissolved and diluted with sodium chloride injection to prepare a solution containing 10 mg of aspartic acid per 1 ml, which is checked according to law (General rule 1142), and the dose is 10ml per 1kg of rabbit body weight, the requirements shall be met. (For injection)
Last Update：2022-01-01 11:30:58
D-2-Aminobutanedioic acid - Content determination
Authoritative Data Verified Data
take this product about 0.lg, precision weighing, add anhydrous formic acid 5ml to dissolve, add glacial acetic acid 30ml, according to the potential titration method (General rule 0701), with perchloric acid titration solution (0.1 mol/L) titration, and the results of the titration were corrected with a blank test. Each 1 ml of perchloric acid titration solution (0.1 mol/L) corresponds to 13.31mg of C4H77NO4.
Last Update：2022-01-01 11:30:58
D-2-Aminobutanedioic acid - Category
Authoritative Data Verified Data
amino acid drugs.
Last Update：2022-01-01 11:30:58
D-2-Aminobutanedioic acid - Storage
Authoritative Data Verified Data
sealed storage.
Last Update：2022-01-01 11:30:58
D-2-Aminobutanedioic acid - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| biological activity | (-)-Aspartic acid is an endogenous NMDA receptor agonist. |
| use | for synthetic drugs, pharmaceutical intermediates or bulk drugs |
Last Update：2024-04-10 22:29:15
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