5-CHLORO-2'-DEOXYURIDINE
5-CHLORO-2'-DEOXYURIDINE
CAS: 50-90-8
Molecular Formula: C9H11ClN2O5
5-CHLORO-2'-DEOXYURIDINE - Names and Identifiers
5-CHLORO-2'-DEOXYURIDINE - Physico-chemical Properties
| Molecular Formula | C9H11ClN2O5 |
| Molar Mass | 262.65 |
| Density | 1.5507 (rough estimate) |
| Melting Point | 176-179°C |
| Solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
| Appearance | Solid |
| Color | White to Off-White |
| pKa | 7.73±0.10(Predicted) |
| Storage Condition | -20°C |
| Refractive Index | 1.6500 (estimate) |
| In vitro study | When 5-Chloro-2’-deoxyuridine (ClDU) is placed into tissue culture medium, mammalian cells incorporate the analog into DNA. It is observed that 10 μM concentration of 5-Chloro-2’-deoxyuridine in the media does not alter cell division kinetics. Previously it has been shown that 5-Chloro-2’-deoxyuridine is metabolized and incorporated into DNA using antibodies that bind selectively to DNA containing halogenated bases. In the studies reported here, 5-Chloro-2’-deoxyuridine is more similar to BrdU in acting as a T analog. The toxicity of 5-Chloro-2’-deoxyuridine could in part be attributed to inhibition of thymidylate synthase. |
5-CHLORO-2'-DEOXYURIDINE - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R40 - Limited evidence of a carcinogenic effect |
| Safety Description | S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| WGK Germany | 3 |
| RTECS | YU7400000 |
| HS Code | 29349990 |
5-CHLORO-2'-DEOXYURIDINE - Reference
| Reference Show more | 1. Pan Wen-Juan, Lin Jia-fu, Wang Xiao-tao, Guo Yi-dong, Yu Yi-Wen, Liu Chao-Lan. Isolation, identification and antibacterial activity of actinomycetes from lakes in Tibet [J]. Biotechnology Bulletin, 2020,36(07):97-103. |
5-CHLORO-2'-DEOXYURIDINE - Reference Information
| biological activity | 5-Chloro-2 '-deoxyuridine, an analog of thymine, it can be used to study the damaging effect of hypochlorous acid on DNA and DNA precursors. |
| category | toxic substances |
| toxicity grade | poisoning |
| Acute toxicity | intraperitoneal-rat LD50: 2000 mg/kg |
| flammability hazard characteristics | flammable; Toxic nitrogen oxides, chloride smoke |
| storage and transportation characteristics | low temperature ventilation and drying |
| fire extinguishing agent | water, carbon dioxide, foam, sand |
Last Update：2024-04-09 02:00:13
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View History
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