4-Chloro-4'-hydroxybenzophenone
4-Chloro-4'-hydroxybenzophenone
CAS: 42019-78-3
Molecular Formula: C13H9ClO2
4-Chloro-4'-hydroxybenzophenone - Names and Identifiers
4-Chloro-4'-hydroxybenzophenone - Physico-chemical Properties
| Molecular Formula | C13H9ClO2 |
| Molar Mass | 232.66 |
| Density | 1.2082 (rough estimate) |
| Melting Point | 177-181 °C |
| Boling Point | 257 °C (13 mmHg) |
| Flash Point | 100 °C |
| Solubility | DMSO (Slightly), Methanol (Slightly, Sonicated) |
| Vapor Presure | 4.17E-07mmHg at 25°C |
| Appearance | White crystal |
| Color | Pale Beige to Light Brown |
| BRN | 2049956 |
| pKa | 7.68±0.15(Predicted) |
| Storage Condition | Inert atmosphere,Room Temperature |
| Refractive Index | 1.5434 (estimate) |
| MDL | MFCD00002357 |
| Physical and Chemical Properties | Melting point 177-181°C boiling point 257°C (13 torr) flash point 100°C |
| Use | As a pharmaceutical fenofibrate Intermediate |
4-Chloro-4'-hydroxybenzophenone - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S24/25 - Avoid contact with skin and eyes. S37/39 - Wear suitable gloves and eye/face protection S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| HS Code | 29144000 |
| Hazard Note | Irritant |
4-Chloro-4'-hydroxybenzophenone - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| use | The impurity of Fenofibric acid (42017-89-0), the active metabolite of fenofibrate which increases Apolipoprotein A- I holmium ediated High-Density Lipoprotein Biogenesis by enhancing transcription of ATP-Bin ding cassette transporter A1 gene in a liver X receptor holmium back ependent manner. used as pharmaceutical fenofibrate intermediate |
| Production method | 1. The reaction method of p-chlorobenzoyl chloride and anisole? ??? After the reaction of p-chlorobenzoyl chloride and anisole, it is prepared by hydrolysis and demethylation. 2. reaction method between p-chlorobenzoyl chloride and phenol????? Dissolve 9.4g(0.1mol) of phenol in 4ml of 10% sodium hydroxide solution, add 14ml(0.110mol) of p-chlorobenzoyl chloride dropwise at 40~45 ℃, add it within 30min, and react at the same temperature for 1h. Cool to room temperature, filter and dry to obtain 22.3g of phenyl p-chlorobenzoate. The yield is 96%, and the melting point is 99~101 ℃. |
Last Update：2024-04-09 15:16:50
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